by Samuel White | 8th February 2024
Pathway Journey Early detection of radiation-induced cardiotoxicity using radionuclide molecular imaging My project looks to develop radionuclide molecular imaging techniques to detect radiotherapy-induced cardiotoxicity earlier than current methods based on...
by Samuel White | 8th February 2024
Pathway Journey PhD Project: Experience dependent plasticity of the zebrafish retina Biography I graduated from the University of Oxford in 2020 with a first-class BA degree in Human Sciences. From here, I joined the MRC DTP. I chose the DTP due to it’s focus on...
by Samuel White | 8th February 2024
Pathway Journey With 1.5 million new infections in 2021, there is a need for an HIV-1 vaccine. While there has been a strong effort to create an HIV vaccine, the incredible mutation rate and diversity of HIV has made it very difficult. Most antibodies induced upon HIV...
by Samuel White | 1st February 2024
Pathway Journey Rotation 1: PERTURBING TDP-43 AUTOREGULATION TO MODEL ALS IN THE ABSENCE OF GENETIC MUTATIONS Rotation 2: INVESTIGATING RIBONUCLEASE 2 EXPRESSING NEUTROPHILS IN TRAUMATIC BRAIN INJURY Rotation 3:GENE THERAPY OF TRAUMATIC BRAIN INJURY USING FOCUSED...
by Samuel White | 1st February 2024
Pathway Journey HIV-1 cell entry is mediated by the viral Env protein that binds CD4 and either CCR5 (R5) or CXCR4 (X4) coreceptors on host T-lymphocytes. Initial infection is typically mediated by R5 viruses while X4 viruses emerge later in infection through HIV-1...
by Samuel White | 30th January 2024
Pathway Journey My PhD focuses on understanding molecular mechanisms in age-related eye diseases (AREDs), including age-related macular degeneration, glaucoma and cataract. I apply statistical and machine learning methods to extensive metabolomics and genomics data...
by Samuel White | 2nd November 2022
Pathway Journey Thesis title: Evaluating the long-term effectiveness of a school-based intervention for anxiety and depression in older adolescents (long-term follow-up of the BESST Trial) This study aims to determine whether DISCOVER, a school-based stress workshop...
by Samuel White | 2nd November 2022
Pathway Journey Rotation projects: CRISPR-mediated tagging of LEM2, MAN1 and BAF for investigation of the role of ESCRT-III/VPS4 in peripheral chromatin organisation; Neutralising antibody responses to SARS-CoV- 2 elicited by the ChAdOx1 nCoV-19 vaccine; Function of...
by Samuel White | 2nd November 2022
Biography My PhD research is focused on the neural representation of trauma memory recall in people who are dual-diagnosed with PTSD and psychosis. Using fMRI and Experience Sampling Method, the aim is to provide a mechanistic understanding of trauma memory recall and...
by Samuel White | 2nd November 2022
Pathway Journey Rotation projects: Investigating viral entry and potential drug candidates for SARS-COV2, Professor Stuart Neil & Dr. Rui Galao Predicting the molecular basis of cancer resistance to radiotherapy, Professor Mahvash Tavassoli & Dr. Shahram...
by Samuel White | 2nd November 2022
Pathway Journey 1. The role of Collectin-11 and the Lectin Complement Pathway in COVID-19 infection 2. SNALP-mediated delivery of the cell-cycle inhibitory molecule miR-199a-3p for stimulation of cardiomyocyte proliferation 3. Establishing a pipeline for the...
by Samuel White | 2nd November 2022
Pathway Journey During my MRes, my first rotation was in Dr Dave Moyes’s group within the Centre for Host-Microbiome (CHMI) interactions. I examined the genetic determinants of antimicrobial resistance in the gut microbiome by screening bacteria and fungi for...
