Sadie Hallett

Pathway 1+3

Cohort 2020

1+3 Student

I graduated from the University of Warwick in 2020 with an integrated masters (MBio) in Biochemistry. During my time at Warwick, my research projects involved purification of a recombinant E. coli seryl-tRNA synthetase for antimicrobial drug discovery and investigation of human seryl-tRNA synthetase mutations associated with a rare form of intellectual disability. I also took part in the 2019 iGEM (International Genetically Engineered Machine) competition where our team ‘Infatuation’ explored the use of lipases to breakdown fatbergs in sewage systems.

I applied for the MRC DTP at King’s because of the diverse and exciting research projects as well as the fantastic training and development opportunities offered by the programme. I also liked the idea of being part of a cohort, to make friends and share the PhD experience with others.

So far, I’ve really enjoyed my three (very different!) rotation projects and I’m really excited to begin my PhD.

Rotation projects:

  • CRISPR-mediated tagging of LEM2, MAN1 and BAF for investigation of the role of ESCRT-III/VPS4 in peripheral chromatin organisation
  • Neutralising antibody responses to SARS-CoV- 2 elicited by the ChAdOx1 nCoV-19 vaccine
  • Function of cell stress-associated RNA-binding proteins in cancer