by admin | 7th September 2022
Scientific basis: The neuronal processing that enables us to see and recognise complex visual images like text and faces starts in the retina itself. Diseases leading to photoreceptor death cause irreversible sight loss, and yet the rest of the inner retinal circuitry...
by admin | 7th September 2022
Overview: Cognitive impairment in people with bipolar disorders (BD) is associated with reduced functional capacity, poor illness prognosis, and poor quality of life. Sleep disturbance is another core BD symptom which may be associated with, and perhaps worsen,...
by admin | 7th September 2022
Clinical prediction modelling is the backbone of precision medicine. However, a recent meta-analysis revealed that most prediction models are not validated in new, real-life settings (external validation) and consequently not considered for implementation in clinical...
by admin | 7th September 2022
Malan syndrome is a rare genetic overgrowth disorder, which is clinically characterized by unusual facial features and macrocephaly associated with intellectual disability. Whilst Nfix transcription factor has been identified as a causal gene of the syndrome, the...
by admin | 7th September 2022
Background Iron dyshomeostasis has been observed in Alzheimer’s Disease (AD) [1]. We have suggested that ferroptosis, a form of iron-enhanced programmed cell death, operates in AD [2], and arises from excess lethal lipids as detoxification mechanisms are overwhelmed...
by admin | 7th September 2022
Congenital heart disease (CHD) affects almost 1% of UK births, and is the most frequent congenital malformation. Improvements in antenatal diagnosis, cardiac surgery, and perioperative care mean that most infants born with CHD now survive. However, children and adults...
by admin | 7th September 2022
Children differ dramatically in how easily they learn skills such as reading and mathematics and in how well they use these skills to learn more generally. These skills are among the most heritable behavioural traits and the DNA revolution is making it possible to...
by admin | 7th September 2022
Tele-health is a core component of the UK mental health care in the NHS 5-year plan. Whilst the implementation was rapidly accelerated during the pandemic, it relies on the technological resources available in the mental health care services and on patients’ ability...
by admin | 7th September 2022
Sexual minority people (e.g., lesbian, gay and bisexual) are at substantially higher risk of multiple health problems, including mental and physical health (Semelyen et al. BMC Psychitr 16, Article 67, 2016). However, the measurement of sexual minority status as...
by admin | 7th September 2022
by admin | 7th September 2022
Eating disorders (EDs) are common and disabling mental disorders. Processes that help or hinder recovery are poorly understood. Remote Measurement Technology (RMT) uses inbuilt sensors in smartphones and/or wearables to: (a) unobtrusively measure human behaviour and...
by admin | 7th September 2022
The brain is made of billions of neurons which communicate with each other via synapses. Synapse formation (synaptogenesis), function, plasticity, and maintenance – processes crucial for normal brain development and function – are all controlled by cholesterol....
