A Lethal Duet of Iron and Toxic Lipids in Alzheimer’s Disease

A Lethal Duet of Iron and Toxic Lipids in Alzheimer’s Disease

Background Iron dyshomeostasis has been observed in Alzheimer’s Disease (AD) [1]. We have suggested that ferroptosis, a form of iron-enhanced programmed cell death, operates in AD [2], and arises from excess lethal lipids as detoxification mechanisms are overwhelmed...

Building the brain- Making and breaking synapses with cholesterol

The brain is made of billions of neurons which communicate with each other via synapses. Synapse formation (synaptogenesis), function, plasticity, and maintenance – processes crucial for normal brain development and function – are all controlled by cholesterol....