by admin | 28th September 2022
In this Pheon Therapeutics co-funded iCASE PhD project, the student will explore the phenomenon of efflux transporter-associated resistance and develop payloads that are less susceptible to efflux. An appropriate choice of payload is critical to developing a...
by admin | 28th September 2022
Traditionally, a cell’s nucleus has been regarded as a passive organelle that stores and protects the genome, facilitating transcription and replication. However, breakthrough studies have revealed it is a dynamic structure and mechanical sensor for physical cues...
by admin | 28th September 2022
The global research into therapeutics for neurodegenerative diseases is rapidly generating new candidate therapeutic approaches, especially new small molecules and gene therapy vectors. However, the bottleneck in translating these to clinical trials is the need to...
by admin | 28th September 2022
Partner: AstraZeneca Eczema is a common and debilitating long-term skin disease caused by changes in the immune system. Recently, research has delivered new drugs for eczema including dupilumab (a biologic) and JAK inhibitor treatments. However, 6 in 10 people who...
by admin | 7th September 2022
Tele-health is a core component of the UK mental health care in the NHS 5-year plan. Whilst the implementation was rapidly accelerated during the pandemic, it relies on the technological resources available in the mental health care services and on patients’ ability...
by admin | 7th September 2022
The brain is made of billions of neurons which communicate with each other via synapses. Synapse formation (synaptogenesis), function, plasticity, and maintenance – processes crucial for normal brain development and function – are all controlled by cholesterol....
by admin | 7th September 2022
Sexual minority people (e.g., lesbian, gay and bisexual) are at substantially higher risk of multiple health problems, including mental and physical health (Semelyen et al. BMC Psychitr 16, Article 67, 2016). However, the measurement of sexual minority status as...
by admin | 7th September 2022
Congenital heart disease (CHD) affects almost 1% of UK births, and is the most frequent congenital malformation. Improvements in antenatal diagnosis, cardiac surgery, and perioperative care mean that most infants born with CHD now survive. However, children and adults...
by admin | 7th September 2022
Background: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease characterised by misregulation of the RNA binding protein TDP-43. A major challenge has been the lack of good TDP-43 disease models, thereby limiting ‘bench to bedside’ success. However,...
by admin | 7th September 2022
Malan syndrome is a rare genetic overgrowth disorder, which is clinically characterized by unusual facial features and macrocephaly associated with intellectual disability. Whilst Nfix transcription factor has been identified as a causal gene of the syndrome, the...
by admin | 7th September 2022
Clinical prediction modelling is the backbone of precision medicine. However, a recent meta-analysis revealed that most prediction models are not validated in new, real-life settings (external validation) and consequently not considered for implementation in clinical...
by admin | 7th September 2022
Overview: Cognitive impairment in people with bipolar disorders (BD) is associated with reduced functional capacity, poor illness prognosis, and poor quality of life. Sleep disturbance is another core BD symptom which may be associated with, and perhaps worsen,...
