by Samuel White | 11th September 2023
Background: The brain is inherently an electrically conductive organ, but standard imaging modalities are not well equipped to measure its electrical properties (EPs). This is particularly relevant for studying neurodevelopment – pre-clinical studies show that...
by Samuel White | 11th September 2023
Scientific basis: Multi-drug resistant bacterial pathogens are frequent causes of hospital acquired infections which are often difficult to diagnose and treat. Pathogenic bacteria produce and small molecules with high iron affinity (Kaff >1025) known as...
by Samuel White | 11th September 2023
Hypertrophic cardiomyopathy (HCM) is a poorly understood, heritable cardiac disease affecting > 1 in 500 persons. HCM is characterised by progressive enlargement of the primary pumping chamber of the heart, the left ventricle, wherein the heart muscle is abnormally...
by Samuel White | 11th September 2023
Background: Cardiac magnetic resonance imaging (CMR) is widely regarded as the gold-standard imaging modality for evaluating cardiac structure, function, and viability. However, a significant rate of non-diagnostic scans (up to 25-50%) is observed in patients with...
by Samuel White | 11th September 2023
Background: Coronary microvascular disease (cMVD) is a syndrome characterised by anginal chest pain, fatigue, and shortness of breath. More prevalent in women, it is caused by dysfunction of the smallest vessels in the heart, causing transient diffuse patchy...
by Samuel White | 11th September 2023
Lung cancer is the leading cause of cancer related death worldwide. The presence of malignant mediastinal lymph nodes (MLNs) is important in determining disease stage and appropriate treatment. Non-invasive screening methods using CT and/or PET have low sensitivity...
by Samuel White | 11th September 2023
Neuroendocrine tumours (NETs) are rare but poor response to chemotherapies results in a
by Samuel White | 11th September 2023
Scientific basis: The neuronal processing that enables us to see and recognise complex visual images like text and faces starts in the retina itself. Diseases leading to photoreceptor death cause irreversible sight loss, and yet the rest of the inner retinal circuitry...
by Samuel White | 11th September 2023
The brain is made of billions of neurons which communicate with each other via synapses. Synapse formation (synaptogenesis), function, plasticity, and maintenance – processes crucial for normal brain development and function – are all controlled by cholesterol....
by Samuel White | 11th September 2023
Children differ dramatically in how easily they learn skills such as reading and mathematics and in how well they use these skills to learn more generally. These skills are among the most heritable behavioural traits and the DNA revolution is making it possible to...
by Samuel White | 11th September 2023
Sexual minority people (e.g., lesbian, gay and bisexual) are at substantially higher risk of multiple health problems, including mental and physical health (Semelyen et al. BMC Psychitr 16, Article 67, 2016). However, the measurement of sexual minority status as...
by Samuel White | 11th September 2023
Congenital heart disease (CHD) affects almost 1% of UK births, and is the most frequent congenital malformation. Improvements in antenatal diagnosis, cardiac surgery, and perioperative care mean that most infants born with CHD now survive. However, children and adults...
