by Samuel White | 11th September 2023
X chromosome inactivation (XCI) occurs early during development in female embryos, ensuring the transcriptional silencing of one of two X chromosomes in somatic cells. Once established, silencing is maintained through subsequent cell divisions, and the inactive X (Xi)...
by Samuel White | 11th September 2023
Adult stem cells drive organ regeneration and homeostasis, but their dysregulation can lead to tumourigenesis or organ failure. Regenerative medicine aims to replace functional cells without triggering uncontrolled proliferation. A barrier to translation is our...
by Samuel White | 11th September 2023
We discovered a conserved process that drives most epithelial cell death called ‘cell extrusion’, essential to maintaining correct cell numbers and an intact barrier. Importantly, misregulation of extrusion drives tumor formation and invasion and asthma inflammation...
by Samuel White | 11th September 2023
Autoimmune destruction of insulin-producing β-cells of the pancreas results in Type 1 Diabetes (T1D), with an incidence rate of 25.4 out of 100,000 (0-14 years) in the UK. Despite improvement of care, to-date, there is no cure for T1D, presenting an urgent need for...
by Samuel White | 11th September 2023
In virtual reality (VR) environments, individuals can be placed in an immersive world where the nature of reality can be inconspicuously manipulated. This state-of-the-art technique has a clear potential for altering exercise workload perception, as altering visual,...
by Samuel White | 11th September 2023
Background: Palmoplantar pustulosis (PPP) is a severe and disabling immune-mediated disease, presenting with painful pustular eruptions on the palms and soles. PPP has a profound impact on quality of life and is very difficult to treat, as its causes are poorly...
by Samuel White | 11th September 2023
Selenium (Se), an essential micronutrient known for its incorporation into antioxidant ‘selenoproteins’, links numerous pathological states from cardiovascular conditions to cancer and aging. Recent investigation on the potential therapeutic role of hydrogen selenide...
by Samuel White | 11th September 2023
RNA-binding proteins (RBPs) coordinate posttranscriptional gene expression via multiple mechanisms, including modulating coding and ncRNA processing and maturation, subcellular localisation or RNA translation. Many RBPs are now known to be deregulated or mutated in...
by Samuel White | 11th September 2023
Background: RSAD2 (viperin) is an iron-sulphur [FeS] enzyme synthesising nucleotide analogue 3’-deoxy-3’,4’-didehydro-CTP (ddhCTP) . The protein expression is induced in response to viral infection and in many cancer cells (Human Protein Atlas). It restricts viral...
by Samuel White | 11th September 2023
Acute and chronic inflammation is damaging to all cell types and contributes to the pathogenesis of a number of diseases, including cardiovascular disease. “Inflamm-aging” is a chronic, sterile, systemic pro-inflammatory status that occurs during ageing. Senescent...
by Samuel White | 11th September 2023
Cleft palate is a relatively common birth defect arising when the palatal shelves growing from the maxilla (upper jaw) fail to meet and fuse. Understanding this developmental process may help early diagnosis and avoid the costs and pain of the repeated surgeries...
by Samuel White | 11th September 2023
Primary or adjuvant radiotherapy or chemo-radiotherapy are part of the curative treatment regime in head and neck squamous cell carcinoma (HNSCC). However, in >50% of high-risk patients, treatment resistance leads to loco-regional disease persistence or recurrence....