by Samuel White | 11th September 2023
Precision medicine approaches are needed to revolutionise management an improve outcomes for patients with inflammatory bowel disease (IBD), a chronic immune mediated inflammatory disease of the gastrointestinal tract without a medical cure. Although there are...
by Samuel White | 11th September 2023
Neural stem cells (NSCs) are self-renewing multipotent progenitors that generate various cell types in the central nervous system (CNS). It is crucial to understand how NSCs regulate proliferation as this controls development, maintenance, and repair of the CNS, as...
by Samuel White | 11th September 2023
During pregnancy insulin resistance increases and the maternal islets of Langerhans adapt by increasing both insulin secretory response and β-cell mass. Gestational diabetes (GDM) occurs when the islets are unable to adapt sufficiently. The signals underlying this...
by Samuel White | 11th September 2023
(i) Gum disease (periodontitis) is the leading cause of tooth loss in adults and is associated with numerous systemic diseases. Following surgical treatment, healing usually occurs by repair, but tissue regeneration is also possible. Current treatment protocols...
by Samuel White | 11th September 2023
Background: Cardiovascular diseases (CVD) are a leading cause of morbidity and mortality. Disruptions of electrophysiological mechanisms in the heart lead to cardiac arrhythmias that affectblood supply to the vital organs, and also greatly increase risks of thrombus...
by Samuel White | 11th September 2023
Background & Motivation: Arrhythmogenic Cardiomyopathy (AC) is a prevalent form of structural heart disease which carries with a high risk of sudden cardiac death due to ventricular arrhythmias. Accurately identifying at risk patients for life-saving implanted...
by Samuel White | 11th September 2023
Aim: To develop a tool that identifies critical abnormalities on MRIbrain scans using deep learning. A clinically validated tool that identifies brain tumours during brain CT or MRI scans does not exist. Immediate identification of a brain tumour potentially allows...
by Samuel White | 11th September 2023
Mapping the structural connectivity of the human brain is one of the main goals of modern neuroscience. Diffusion MRI tractography is the only method that allows researchers probing white matter connections in-vivo, making it a unique tool for research and clinical...
by Samuel White | 11th September 2023
Gestational hypertensive disorders, with preeclampsia (PE, incidence 4-7%) at their extreme end, are a leading cause of maternal death and a major cause of perinatal mortality and morbidity. They also come with a lifelong increased risk for cardiovascular disease. The...
by Samuel White | 11th September 2023
Parallel-transmit (pTx) ultra-high field MRI using multiple radiofrequency (RF) transmitters demonstrates impressive advantages for high-resolution anatomic and functional imaging of the human body. By adjusting the RF phases and amplitude of individual transmitters...
by Samuel White | 11th September 2023
The project aims to develop an automated, machine learning (ML) enabled spontaneous venous pulsation (SVP) detection system, first for widely available optical coherence tomography (OCT) fundal videography, and second for videos acquired from hand-held retinal fundus...
by Samuel White | 11th September 2023
Scientific basis / background: Stablishing the causes (i.e. aetiology) of cardiovascular conditions such as hypertension is key for their effective and efficient management. We at KCL have generated initial promising evidence that the heart remodels its 3D anatomy in...