by Samuel White | 11th September 2023
Functional Neurological Disorders (FNDs) are common causes of neurological symptoms such as seizures, limb weakness, movement disorders and sensory changes without structural neuropathology. There is increasing evidence of an association with autism in both adults and...
by Samuel White | 11th September 2023
Mutations in EPG5 cause Vici Syndrome, a neurodevelopmental disease associated with subsequent neurodegeneration. EPG5 encodes for a protein that regulates autophagy, by controlling the fusion between autophagosomes and lysosomes. Autophagy is an essential...
by Samuel White | 11th September 2023
Introduction: There is a potential link between neurodegenerative diseases and disordered proteins forming amyloids, which subsequently trigger calcification of brain tissues. In our research laboratories, we have discovered indicative calcification patterns occurring...
by Samuel White | 11th September 2023
Background: Acknowledging sleep health as a key marker of overall health and the adoption of a systems approach to its study, promotion, and amelioration led to major developments in sleep research. Sleep is recognised as a proxy of health rather than the mere...
by Samuel White | 11th September 2023
Neurodevelopmental Disorders (NDD), including intellectual disability and autism spectrum disorder, are a common group of conditions, affecting up to 3% of the general population, with significant societal impact. Yet, the molecular and cellular mechanisms disrupting...
by Samuel White | 11th September 2023
Chronic pain is a complex and distressing problem affecting ~1 billion people world-wide – equivalent to the population of China. We know that how we think and feel about our bodies can influence pain perception and the risk of developing chronic pain. What we don’t...
by Samuel White | 11th September 2023
At present, there are no medications for treatment of Autism core or co-occurring symptoms. There is evidence that the neurobiological underpinnings of ASD include aberrations in brain growth, neuronal patterning, cortical connectivity and altered molecular pathways...
by Samuel White | 11th September 2023
Adolescents are thought to be more vulnerable to the harmful effects of cannabis than adults. Adolescents are reliably at a greater risk of developing cannabis use disorder (CUD) than adults. Cannabis addiction is the leading cause of 75% of cases). However, the...
by Samuel White | 11th September 2023
Traumatic experiences are common, and often followed by emotional disorders (anxiety, depression, post-traumatic stress disorder (PTSD)). Nonetheless, most people who experience trauma do not develop an emotional disorder. These individual differences in developing...
by Samuel White | 11th September 2023
Epilepsy is typically understood as a disease where the brain represents a complex network with regions and/or sub-networks in which normal excitation/inhibition (E/I) balance is perturbed. The resulting repertoire of dynamics includes adverse effects such as...
by Samuel White | 11th September 2023
Anorexia nervosa (AN) is a disabling disorder typically beginning in adolescence. ~30% of patients respond poorly to psychotherapies, resulting in enduring illness, and the potential to impair development. We have pioneered non-invasive brain stimulation treatments in...
by Samuel White | 11th September 2023
The scientific basis of the project and (optional) translational aspects of the project, It was previously thought that depression preceded low self-esteem and that once the depression was treated, then self-esteem would also improve. However, a number of longitudinal...
