by admin | 7th September 2022
At present, there are no medications for treatment of Autism core or co-occurring symptoms. There is evidence that the neurobiological underpinnings of ASD include aberrations in brain growth, neuronal patterning, cortical connectivity and altered molecular pathways...
by admin | 7th September 2022
The generation of skilled upper limb movements relies on a complex neuronal network including several cerebral cortical and sub-cortical areas. The processing of multi-modal sensory information and its efficient transfer across this network are critical to produce...
by admin | 7th September 2022
Alcohol Use Disorder (AUD) is a highly prevalent disorder. The World Health Organisation has estimated that approximately 3 million people die each year from the harmful use of alcohol. Psychological interventions and pharmacological treatments are widely available,...
by admin | 7th September 2022
Chronic pain is a complex and distressing problem affecting ~1 billion people world-wide – equivalent to the population of China. We know that how we think and feel about our bodies can influence pain perception and the risk of developing chronic pain. What we don’t...
by admin | 7th September 2022
Neurodevelopmental Disorders (NDD), including intellectual disability and autism spectrum disorder, are a common group of conditions, affecting up to 3% of the general population, with significant societal impact. Yet, the molecular and cellular mechanisms disrupting...
by admin | 7th September 2022
Background: Acknowledging sleep health as a key marker of overall health and the adoption of a systems approach to its study, promotion, and amelioration led to major developments in sleep research. Sleep is recognised as a proxy of health rather than the mere...
by admin | 7th September 2022
Introduction: There is a potential link between neurodegenerative diseases and disordered proteins forming amyloids, which subsequently trigger calcification of brain tissues. In our research laboratories, we have discovered indicative calcification patterns occurring...
by admin | 7th September 2022
Mutations in EPG5 cause Vici Syndrome, a neurodevelopmental disease associated with subsequent neurodegeneration. EPG5 encodes for a protein that regulates autophagy, by controlling the fusion between autophagosomes and lysosomes. Autophagy is an essential...
by admin | 7th September 2022
Mitochondria generate ATP, play key roles in cellular metabolism and are essential for neuronal function. Increasing evidence points to a central role of mitochondria in the aetiology of neuropsychiatric disorders, including schizophrenia, depression and anxiety....
by admin | 7th September 2022
The scientific basis of the project and (optional) translational aspects of the project, It was previously thought that depression preceded low self-esteem and that once the depression was treated, then self-esteem would also improve. However, a number of longitudinal...
by admin | 7th September 2022
Anorexia nervosa (AN) is a disabling disorder typically beginning in adolescence. ~30% of patients respond poorly to psychotherapies, resulting in enduring illness, and the potential to impair development. We have pioneered non-invasive brain stimulation treatments in...
by admin | 7th September 2022
Epilepsy is typically understood as a disease where the brain represents a complex network with regions and/or sub-networks in which normal excitation/inhibition (E/I) balance is perturbed. The resulting repertoire of dynamics includes adverse effects such as...
