by admin | 7th September 2022
Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in approx. 1.5 per 1000 live births at term and is associated with significant mortality and long-term morbidity, up to 50% of neonates having a severe outcome of death or disability. Outcomes can also include...
by admin | 7th September 2022
Cytoplasmic accumulation and nuclear depletion of TDP43 are key pathological hallmarks of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) (1). While there is progress in understanding disease progression, the early presymptomatic (prodromal) stages...
by admin | 7th September 2022
Epilepsy is the most common and highest impact neurological disorder and there are no medical cures because the pathophysiological brain mechanisms are poorly understood. The condition arises from excitation-inhibition imbalance in neocortical networks, with...
by admin | 7th September 2022
The role of mitochondria in complex diseases such as Parkinson’s Disease and Motor Neurone Disease is now becoming well established, however it is often not known whether altered mitochondrial processes play a causal role in developing disease, or occur as a...
by admin | 7th September 2022
In this project we will use a coherent in vitro, experimental, systematic approach, to mimic early-life stress (ELS)-relevant cortisol and inflammatory insults on cells from the human brain, heart, liver, pancreas and blood immune system, to identify mechanisms...
by admin | 7th September 2022
Migraine is the leading cause of years lost to disability in young females, impacting over 1-billion people globally. Sleep, under the regulation of circadian and light-dark cycles is intrinsically linked with migraine, with sleep disruption a commonly reported...
by admin | 7th September 2022
Around 70% of children with autism have at least one additional psychiatric diagnosis, with emotional and behavioural problems being the most diagnosed and often requiring specialist interventions by mental health services. However, there is a poor understanding of...
by admin | 7th September 2022
Atypical depression (AD) is characterised by mood reactivity, interpersonal rejection sensitivity, hyperphagia, hypersomnia and/or leaden immobility (DSM-IV). Atypical features are reported in 15-30% of patients with major depression, and are associated with early...
by admin | 7th September 2022
mRNAs are found not only in neuronal cell bodies but also in axons and dendrites, where many re locally translated. These local mechanisms are important for proper neuronal development and adult neurological functions. Alternative splicing of mRNAs produces various...
by admin | 7th September 2022
Autophagy is a self-degradation mechanism necessary to clear aggregate prone proteins that accumulate in neurodegenerative diseases such as in Alzheimer’s disease (AD). For this reason, investigating the mechanisms that regulate autophagy are currently explored as...
by admin | 7th September 2022
Remote measurement technology (RMT) has transformed longitudinal remote monitoring of research participants and offers unique translational potential. This project uses data from our large RMT study on adults and adolescents with attention deficit hyperactivity...
by admin | 7th September 2022
To mitigate the ill consequences of psychosis on people’s life, the NHS and the economy, clinicians increasingly focus on early intervention. Here, the aim is to prevent psychosis from occurring in people at risk of the condition. One way to improve our ability to...
