by Samuel White | 11th September 2023
Background: Abnormalities of the neurotransmitter system GABA are consistent findings in post-mortem and preclinical studies in psychosis. GABAergic abnormalities have been linked to not only psychotic symptoms but also cognitive deficits that are not treated...
by Samuel White | 11th September 2023
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two clinically different neurodegenerative diseases that lie on a pathogenic spectrum. The most common pathology present in ALS and FTD cases is cytoplasmic mislocalisation and aggregation of...
by Samuel White | 11th September 2023
Laws regulating cannabis are rapidly changing globally, with Uruguay, Canada, and several US states now permitting recreational use. Concurrently, cannabis potency (of ∆9-tetrahydrocannabinol, THC) has increased in most parts of the world, and research suggests...
by Samuel White | 11th September 2023
Change in appetite and weight are core symptoms of depression, but little is known about the relationship between them and their biological underpinnings. The genetic contribution to most mental health disorders and human behaviour is polygenic, with many genetic...
by Samuel White | 11th September 2023
Remote measurement technology (RMT) has transformed longitudinal remote monitoring of research participants and offers unique translational potential. This project uses data from our large RMT study on adults and adolescents with attention deficit hyperactivity...
by Samuel White | 11th September 2023
Autophagy is a self-degradation mechanism necessary to clear aggregate prone proteins that accumulate in neurodegenerative diseases such as in Alzheimer’s disease (AD). For this reason, investigating the mechanisms that regulate autophagy are currently explored as...
by Samuel White | 11th September 2023
mRNAs are found not only in neuronal cell bodies but also in axons and dendrites, where many re locally translated. These local mechanisms are important for proper neuronal development and adult neurological functions. Alternative splicing of mRNAs produces various...
by Samuel White | 11th September 2023
Atypical depression (AD) is characterised by mood reactivity, interpersonal rejection sensitivity, hyperphagia, hypersomnia and/or leaden immobility (DSM-IV). Atypical features are reported in 15-30% of patients with major depression, and are associated with early...
by Samuel White | 11th September 2023
Around 70% of children with autism have at least one additional psychiatric diagnosis, with emotional and behavioural problems being the most diagnosed and often requiring specialist interventions by mental health services. However, there is a poor understanding of...
by Samuel White | 11th September 2023
The role of mitochondria in complex diseases such as Parkinson’s Disease and Motor Neurone Disease is now becoming well established, however it is often not known whether altered mitochondrial processes play a causal role in developing disease, or occur as a...
by Samuel White | 11th September 2023
Cytoplasmic accumulation and nuclear depletion of TDP43 are key pathological hallmarks of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) (1). While there is progress in understanding disease progression, the early presymptomatic (prodromal) stages...
by Samuel White | 11th September 2023
Background: Anorexia nervosa (AN) is a serious psychiatric condition with the highest mortality rate of any psychiatric illness. The factors that perpetuate and maintain the illness remain elusive and in particular, understanding surrounding the neurobiology of AN is...
