by Samuel White | 11th September 2023
Mitochondria generate ATP, play key roles in cellular metabolism and are essential for neuronal function. Increasing evidence points to a central role of mitochondria in the aetiology of neuropsychiatric disorders, including schizophrenia, depression and anxiety....
by Samuel White | 11th September 2023
Mutations in epigenetic regulators have emerged as a significant risk factor for a diverse group of neurodevelopmental disorders, with most characterised by autism and intellectual disability. We have generated mouse models with mutations in these high risk genes that...
by Samuel White | 11th September 2023
The unique experience of pain is driven in part by the descending pain modulatory system (DPMS). Activity in DPMS-encompassed descending inhibitory pathways is altered in some chronic pain states. This PhD proposal is concerned with mapping the mechanisms that...
by Samuel White | 11th September 2023
Fibromyalgia is an incurable condition characterized by chronic widespread pain, fatigue, and emotional distress. Despite that >2% (mostly women) of the population live with fibromyalgia, there are no effective therapies. The mechanisms responsible remained unknown...
by Samuel White | 11th September 2023
Cell cycle dysfunction, increased oxidant production and altered metabolism are widely associated with hyper-proliferative vascular diseases. Understanding the link is crucial for developing therapeutics to halt vascular remodelling or promote its regression....
by Samuel White | 11th September 2023
Acute myeloid leukaemia (AML) in children remains a significant unmet. Most paediatric AML are characterised by gene fusions associated to clinical prognosis. This project aims to define the immunogenicity of noncanonical antigenic peptides derived from fusion genes...
by Samuel White | 11th September 2023
Muscular dystrophies are a group of diseases that are characterised by muscle weakness, where muscle wastes and connective tissue becomes deregulated, so scar tissue forms. Oxidative stress from respiration is common to many muscular dystrophies. A common muscular...
by Samuel White | 11th September 2023
This project, using data collected as part of the MRC-funded UNiCoRN Study (Understanding the causes of Hyperglycaemia in Pregnancy; MR/W003740/1) will explore the physiology of normal pregnancy across the spectrum of glycaemia, in this 750-strong prospective cohort...
by Samuel White | 11th September 2023
Severe refractory asthma is characterised by neutrophil-dominated lung inflammation. Neutrophils’ capacity to produce reactive oxygen species (ROS) via enzyme NADPH oxidase Nox2 is unmet by other immune cells. Neutrophil Nox2 represents the main source of superoxide...
by Samuel White | 11th September 2023
The junctional epithelium (JE) is an important group of epithelial cells that reside between the tooth and the oral mucosa. At the base of the JE is a putative epithelial stem cell niche (*) that replenishes the junctional epithelium. The region is defined by the...
by Samuel White | 11th September 2023
The innate immune system is the first line of defence against pathogens. When a bacteria or virus is sensed by our cells, there is potent upregulation of pro-inflammatory cytokines and other genes, which are critical to stop the infection. However, if inflammation is...
by Samuel White | 11th September 2023
More than 50% of people aged over 65 have age-related hearing impairment (ARHI). ARHI has considerable impact on health and well-being, from mild difficulty with communication to depression, social isolation and dementia. ARHI is heritable (h2=40%) but the underlying...
