by Samuel White | 1st March 2023
Partner: M Square Life 3rd Supervisor: Dr Neveen Hosny Project: Traditionally, a cell’s nucleus has been regarded as a passive organelle that stores and protects the genome, facilitating transcription and replication. However, breakthrough studies have...
by Samuel White | 1st March 2023
Partner: ISDI – Image Sensor Design & Innovation 3rd Supervisor: Thalis Anaxagoras Project: We aim to understand how prenatal therapy can be used to treat sickle cell disease (SCD) by developing a nanoparticle delivery system to encapsulate gene-editing tools in...
by Samuel White | 1st March 2023
Partner: F. Hoffmann-La Roche 3rd Supervisor: Nuria Gutierrez-Prat Project: Oncogene addiction is defined as the unusual dependence of certain cancer cells to the activity of aberrantly activated gene products. These dependencies can be targeted therapeutically...
by Samuel White | 1st March 2023
Partner: Mediso Medical Imaging Systems 3rd Supervisor: Tim Witney Project: Radionuclide-based theranostics, where targeted diagnostic and therapeutic radiopharmaceuticals are combined for the precision treatment of cancer, has revolutionised the field of...
by Samuel White | 1st March 2023
Partner: Quell Therapeutics Limited Project: The prevalence of chronic liver disease, the 5th most common cause of death in the UK is rising sharply mainly due to the increasing load of viral hepatitis, alcohol- related liver disease and non-alcoholic fatty...
by Samuel White | 1st March 2023
Partner: Brain Products GmbH 3rd Supervisor: Tracy Warbrick Project: For adults and children with focal epilepsy, surgical removal of the brain region responsible for seizure generation is the only possible complete cure. This can remove dependence on...
by admin | 28th September 2022
An appropriate choice of payload is critical to developing a successful ADC for clinical development1. Developability problems such as efflux liability, non-selective toxicity, chemoresistance, poor pharmacokinetic and pharmacodynamic profiles of existing payloads are...
by admin | 7th September 2022
Children differ dramatically in how easily they learn skills such as reading and mathematics and in how well they use these skills to learn more generally. These skills are among the most heritable behavioural traits and the DNA revolution is making it possible to...
by admin | 7th September 2022
Project Description: Research has shown that women experience more symptoms of depression and are more likely to be diagnosed with depression than men. These differences in prevalence only become evident after the onset of puberty. This raises the possibility that...
by admin | 7th September 2022
Sexual minority people (e.g., lesbian, gay and bisexual) are at substantially higher risk of multiple health problems, including mental and physical health (Semelyen et al. BMC Psychitr 16, Article 67, 2016). However, the measurement of sexual minority status as...
by admin | 7th September 2022
Congenital heart disease (CHD) affects almost 1% of UK births, and is the most frequent congenital malformation. Improvements in antenatal diagnosis, cardiac surgery, and perioperative care mean that most infants born with CHD now survive. However, children and adults...
by admin | 7th September 2022
Malan syndrome is a rare genetic overgrowth disorder, which is clinically characterized by unusual facial features and macrocephaly associated with intellectual disability. Whilst Nfix transcription factor has been identified as a causal gene of the syndrome, the...
