by admin | 28th September 2022
Traditionally, a cell’s nucleus has been regarded as a passive organelle that stores and protects the genome, facilitating transcription and replication. However, breakthrough studies have revealed it is a dynamic structure and mechanical sensor for physical cues...
by admin | 28th September 2022
Partner: AstraZeneca Eczema is a common and debilitating long-term skin disease caused by changes in the immune system. Recently, research has delivered new drugs for eczema including dupilumab (a biologic) and JAK inhibitor treatments. However, 6 in 10 people who...
by admin | 28th September 2022
In this Pheon Therapeutics co-funded iCASE PhD project, the student will explore the phenomenon of efflux transporter-associated resistance and develop payloads that are less susceptible to efflux. An appropriate choice of payload is critical to developing a...
by admin | 28th September 2022
The global research into therapeutics for neurodegenerative diseases is rapidly generating new candidate therapeutic approaches, especially new small molecules and gene therapy vectors. However, the bottleneck in translating these to clinical trials is the need to...
by admin | 7th September 2022
Eating disorders (EDs) are common and disabling mental disorders. Processes that help or hinder recovery are poorly understood. Remote Measurement Technology (RMT) uses inbuilt sensors in smartphones and/or wearables to: (a) unobtrusively measure human behaviour and...
by admin | 7th September 2022
Background Iron dyshomeostasis has been observed in Alzheimer’s Disease (AD) [1]. We have suggested that ferroptosis, a form of iron-enhanced programmed cell death, operates in AD [2], and arises from excess lethal lipids as detoxification mechanisms are overwhelmed...
by admin | 7th September 2022
Background: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease characterised by misregulation of the RNA binding protein TDP-43. A major challenge has been the lack of good TDP-43 disease models, thereby limiting ‘bench to bedside’ success. However,...
by admin | 7th September 2022
Clinical prediction modelling is the backbone of precision medicine. However, a recent meta-analysis revealed that most prediction models are not validated in new, real-life settings (external validation) and consequently not considered for implementation in clinical...
by admin | 7th September 2022
Tele-health is a core component of the UK mental health care in the NHS 5-year plan. Whilst the implementation was rapidly accelerated during the pandemic, it relies on the technological resources available in the mental health care services and on patients’ ability...
by admin | 7th September 2022
Overview: Cognitive impairment in people with bipolar disorders (BD) is associated with reduced functional capacity, poor illness prognosis, and poor quality of life. Sleep disturbance is another core BD symptom which may be associated with, and perhaps worsen,...
by admin | 7th September 2022
In the UK, and globally, fatal drug overdoses are at an all-time high1,2. Opioid overdose is now the leading cause of death for people under the age of 50 in the US2. An effective antidote to opioid, Naloxone, exists but many people are alone when they overdose3,4 and...
by admin | 7th September 2022
People with autism are much more likely to experience mental health difficulties than the general population; around 70% have at least one comorbid psychiatric disorder. We have developed a novel, specialist care pathway for this population in close collaboration with...
