by admin | 7th September 2022
The brain is made of billions of neurons which communicate with each other via synapses. Synapse formation (synaptogenesis), function, plasticity, and maintenance – processes crucial for normal brain development and function – are all controlled by cholesterol....
by admin | 7th September 2022
Many people with major depressive disorder (MDD) are ambivalent about medication or therapeutic relationships. Self-guided virtual-reality(VR)-assisted therapy is a promising approach to meet their needs. In this project, based on our previous VR-based self-assessment...
by admin | 7th September 2022
Around 70% of children with autism have at least one additional psychiatric diagnosis, with emotional and behavioural problems being the most diagnosed and often requiring specialist interventions by mental health services. However, there is a poor understanding of...
by admin | 7th September 2022
Atypical depression (AD) is characterised by mood reactivity, interpersonal rejection sensitivity, hyperphagia, hypersomnia and/or leaden immobility (DSM-IV). Atypical features are reported in 15-30% of patients with major depression, and are associated with early...
by admin | 7th September 2022
mRNAs are found not only in neuronal cell bodies but also in axons and dendrites, where many re locally translated. These local mechanisms are important for proper neuronal development and adult neurological functions. Alternative splicing of mRNAs produces various...
by admin | 7th September 2022
Autophagy is a self-degradation mechanism necessary to clear aggregate prone proteins that accumulate in neurodegenerative diseases such as in Alzheimer’s disease (AD). For this reason, investigating the mechanisms that regulate autophagy are currently explored as...
by admin | 7th September 2022
Remote measurement technology (RMT) has transformed longitudinal remote monitoring of research participants and offers unique translational potential. This project uses data from our large RMT study on adults and adolescents with attention deficit hyperactivity...
by admin | 7th September 2022
Change in appetite and weight are core symptoms of depression, but little is known about the relationship between them and their biological underpinnings. The genetic contribution to most mental health disorders and human behaviour is polygenic, with many genetic...
by admin | 7th September 2022
Laws regulating cannabis are rapidly changing globally, with Uruguay, Canada, and several US states now permitting recreational use. Concurrently, cannabis potency (of ∆9-tetrahydrocannabinol, THC) has increased in most parts of the world, and research suggests...
by admin | 7th September 2022
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two clinically different neurodegenerative diseases that lie on a pathogenic spectrum. The most common pathology present in ALS and FTD cases is cytoplasmic mislocalisation and aggregation of...
by admin | 7th September 2022
Background: Abnormalities of the neurotransmitter system GABA are consistent findings in post-mortem and preclinical studies in psychosis. GABAergic abnormalities have been linked to not only psychotic symptoms but also cognitive deficits that are not treated...
by admin | 7th September 2022
Scientific Basis: The WHO considers autism as a priority due to its high-frequency, early onset, and life-long impact on quality of life. Discovering mechanisms that predict which autistic person develops mental health problems (prognostic biomarker), and which...
