by Samuel White | 11th September 2023
Aim: To develop a tool that identifies critical abnormalities on MRIbrain scans using deep learning. A clinically validated tool that identifies brain tumours during brain CT or MRI scans does not exist. Immediate identification of a brain tumour potentially allows...
by Samuel White | 11th September 2023
Background & Motivation: Arrhythmogenic Cardiomyopathy (AC) is a prevalent form of structural heart disease which carries with a high risk of sudden cardiac death due to ventricular arrhythmias. Accurately identifying at risk patients for life-saving implanted...
by Samuel White | 11th September 2023
Background: Cardiovascular diseases (CVD) are a leading cause of morbidity and mortality. Disruptions of electrophysiological mechanisms in the heart lead to cardiac arrhythmias that affectblood supply to the vital organs, and also greatly increase risks of thrombus...
by Samuel White | 11th September 2023
Recent epidemiological studies established an association between transient maternal hypothyroidism in early pregnancy and autism spectrum disorder (ASD). We have developed a robust mouse model of ASD where offspring born from a mother with induced transient...
by Samuel White | 11th September 2023
Respiratory failure is the leading cause of morbidity and mortality following spinal cord injury (Fig 1). There currently exists no clinical treatment for this and respiratory muscle function is not typically monitored following spinal cord injury. We hypothesise that...
by Samuel White | 11th September 2023
Up to 40% of autistic individuals have epilepsy. The combination of autism and epilepsy significantly impacts upon quality of life as well as physical and mental health. The majority of studies to date have been retrospective investigations after a diagnosis of autism...
by Samuel White | 11th September 2023
Human induced pluripotent stem cells (hiPSCs) derived from patients with neurological disease are an invaluable source to study the development of central nervous system disorders such as epilepsy. In a novel approach, we will investigate if hiPSCs from epilepsy...
by Samuel White | 11th September 2023
People with autism are much more likely to experience mental health difficulties than the general population; around 70% have at least one comorbid psychiatric disorder. We have developed a novel, specialist care pathway for this population in close collaboration with...
by Samuel White | 11th September 2023
In the UK, and globally, fatal drug overdoses are at an all-time high1,2. Opioid overdose is now the leading cause of death for people under the age of 50 in the US2. An effective antidote to opioid, Naloxone, exists but many people are alone when they overdose3,4 and...
by Samuel White | 11th September 2023
Overview: Cognitive impairment in people with bipolar disorders (BD) is associated with reduced functional capacity, poor illness prognosis, and poor quality of life. Sleep disturbance is another core BD symptom which may be associated with, and perhaps worsen,...
by Samuel White | 11th September 2023
Tele-health is a core component of the UK mental health care in the NHS 5-year plan. Whilst the implementation was rapidly accelerated during the pandemic, it relies on the technological resources available in the mental health care services and on patients’ ability...
by Samuel White | 11th September 2023
Background: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease characterised by misregulation of the RNA binding protein TDP-43. A major challenge has been the lack of good TDP-43 disease models, thereby limiting ‘bench to bedside’ success. However,...
