by Samuel White | 11th September 2023
Primary or adjuvant radiotherapy or chemo-radiotherapy are part of the curative treatment regime in head and neck squamous cell carcinoma (HNSCC). However, in >50% of high-risk patients, treatment resistance leads to loco-regional disease persistence or recurrence....
by Samuel White | 11th September 2023
Background: RSAD2 (viperin) is an iron-sulphur [FeS] enzyme synthesising nucleotide analogue 3’-deoxy-3’,4’-didehydro-CTP (ddhCTP) . The protein expression is induced in response to viral infection and in many cancer cells (Human Protein Atlas). It restricts viral...
by Samuel White | 11th September 2023
Adult stem cells drive organ regeneration and homeostasis, but their dysregulation can lead to tumourigenesis or organ failure. Regenerative medicine aims to replace functional cells without triggering uncontrolled proliferation. A barrier to translation is our...
by Samuel White | 11th September 2023
Cancer metastasis accounts for most cancer-related deaths. To invade surrounding tissues, cancer cells need to migrate through dense and constricted spaces, which results in high mechanical stress on the nucleus, a large and stiff organelle. This can lead to nuclear...
by Samuel White | 11th September 2023
Half of patients with melanoma, the most lethal skin cancer, and a large proportion of patients with aggressive breast cancers such as the triple negative subtypes, do not respond to currently-available antibody immunotherapies. Existing anti-cancer antibody-based...
by Samuel White | 11th September 2023
Background: Pancreatic cancer is one of the most lethal cancers in humans. There is a high unmet medical need to develop new therapies for the treatment of this disease. Drugs which engage the immune system (immunotherapies) have shown a survival benefit in lung...
by Samuel White | 11th September 2023
Proteolysis-targeting chimeras (PROTACs) are an emerging new therapeutic class of drugs with the potential to open “drug target space” not accessible to conventional small molecule drugs. PROTACs have potential applications in many diseases, with their potential as...
by Samuel White | 11th September 2023
An area of untapped potential in drug development is the so-called undruggable space. Undruggable proteins are defined as those unable to be pharmacologically targeted via conventional small molecule drugs. In recent years, new modalities have arisen that have the...
by Samuel White | 11th September 2023
One of the first points of contact of pathogenic coronaviruses during infection is the lung alveolar epithelium. A consequence of infection of these cells is a dysregulated inflammatory response typified by hyper-production of inflammatory mediators that leads to an...
by Samuel White | 11th September 2023
How cells tell the difference between their own mRNAs and RNA species of potential viral origin is an essential part of the first line of defence in mammals. TRIM25 is a member of the Tripartite Motif family of E3 ubiquitin ligases that plays a central role in innate...
by Samuel White | 11th September 2023
Scientific basis Systemic Lupus Erythematosus is a chronic, multi-system autoimmune disease, with increased disease severity in non-European ancestries and more females than males with lupus. The relapsing-remitting disease course makes it challenging to treat...
by Samuel White | 11th September 2023
Age is the biggest risk factor for cancer with more than half of cases diagnosed in people over the age of 60. Ageing is associated with a heightened inflammatory state called – Inflammageing – that is likely related to the aetiology of age-related diseases....
