Regulation of neural stem cell quiescence by ribosomal activity

Project Description: Neural stem cells (NSCs) are self-renewing multipotent progenitors that generate various cell types in the central nervous system (CNS). It is crucial to understand how NSCs regulate proliferation as this controls development, maintenance, and...
Regulation of the innate immune response by N4BP1

Regulation of the innate immune response by N4BP1

The innate immune system is the first line of defence against pathogens. When a bacteria or virus is sensed by our cells, there is potent upregulation of pro-inflammatory cytokines and other genes, which are critical to stop the infection. However, if inflammation is...
Generation of in vitro models of low grade gliomas

Generation of in vitro models of low grade gliomas

Diffuse infiltrating low-grade gliomas (LGGs) are WHO grade 2 tumours that include oligodendrogliomas and astrocytomas. Despite their initially indolent nature, LGGs may cause considerable morbidity1 and frequently transform into higher grade lethal entities 2. The...
Redox-regulation in neutrophilic asthma

Redox-regulation in neutrophilic asthma

Severe refractory asthma is characterised by neutrophil-dominated lung inflammation. Neutrophils’ capacity to produce reactive oxygen species (ROS) via enzyme NADPH oxidase Nox2 is unmet by other immune cells. Neutrophil Nox2 represents the main source of superoxide...
Regenerative therapies for muscle-wasting diseases

Regenerative therapies for muscle-wasting diseases

Muscular dystrophies are a group of diseases that are characterised by muscle weakness, where muscle wastes and connective tissue becomes deregulated, so scar tissue forms. Oxidative stress from respiration is common to many muscular dystrophies. A common muscular...