by admin | 28th September 2022
In this Pheon Therapeutics co-funded iCASE PhD project, the student will explore the phenomenon of efflux transporter-associated resistance and develop payloads that are less susceptible to efflux. An appropriate choice of payload is critical to developing a...
by admin | 28th September 2022
Partner: AstraZeneca Eczema is a common and debilitating long-term skin disease caused by changes in the immune system. Recently, research has delivered new drugs for eczema including dupilumab (a biologic) and JAK inhibitor treatments. However, 6 in 10 people who...
by admin | 7th September 2022
Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by inefficient haematopoiesis, morphologic dysplasia and peripheral cytopenia(s). Several drugs have been tested and approved to treat MDS, including hypomethylating agent 5-azacytidine (AZA)....
by admin | 7th September 2022
Project Description: Neural stem cells (NSCs) are self-renewing multipotent progenitors that generate various cell types in the central nervous system (CNS). It is crucial to understand how NSCs regulate proliferation as this controls development, maintenance, and...
by admin | 7th September 2022
Cellular plasticity, the ability of a cell to adopt alternative fates or acquire new identities, is relevant to diverse fields, including developmental and stem cell biology, regenerative medicine. Insights into these mechanisms could provide us with tools for...
by admin | 7th September 2022
More than 50% of people aged over 65 have age-related hearing impairment (ARHI). ARHI has considerable impact on health and well-being, from mild difficulty with communication to depression, social isolation and dementia. ARHI is heritable (h2=40%) but the underlying...
by admin | 7th September 2022
The innate immune system is the first line of defence against pathogens. When a bacteria or virus is sensed by our cells, there is potent upregulation of pro-inflammatory cytokines and other genes, which are critical to stop the infection. However, if inflammation is...
by admin | 7th September 2022
The junctional epithelium (JE) is an important group of epithelial cells that reside between the tooth and the oral mucosa. At the base of the JE is a putative epithelial stem cell niche (*) that replenishes the junctional epithelium. The region is defined by the...
by admin | 7th September 2022
Diffuse infiltrating low-grade gliomas (LGGs) are WHO grade 2 tumours that include oligodendrogliomas and astrocytomas. Despite their initially indolent nature, LGGs may cause considerable morbidity1 and frequently transform into higher grade lethal entities 2. The...
by admin | 7th September 2022
Severe refractory asthma is characterised by neutrophil-dominated lung inflammation. Neutrophils’ capacity to produce reactive oxygen species (ROS) via enzyme NADPH oxidase Nox2 is unmet by other immune cells. Neutrophil Nox2 represents the main source of superoxide...
by admin | 7th September 2022
This project, using data collected as part of the MRC-funded UNiCoRN Study (Understanding the causes of Hyperglycaemia in Pregnancy; MR/W003740/1) will explore the physiology of normal pregnancy across the spectrum of glycaemia, in this 750-strong prospective cohort...
by admin | 7th September 2022
Muscular dystrophies are a group of diseases that are characterised by muscle weakness, where muscle wastes and connective tissue becomes deregulated, so scar tissue forms. Oxidative stress from respiration is common to many muscular dystrophies. A common muscular...
