by Samuel White | 11th September 2023
Are the lipids forming the plasma membrane, organelles and nuclear envelope (NE) dynamically modified under mechanical stress? Lipids and proteins are key components of membranes, yet most of the effort to understand mechanotransduction has focused on proteins alone....
by Samuel White | 11th September 2023
The nucleus is a key eukaryotic organelle that must grow and restructure in each cell cycle. Tight control of nuclear shape and size is essential for proper cell function, and aberrant regulation of interphase nuclear morphology has been implicated in aging and...
by Samuel White | 11th September 2023
High blood pressure evolving into hypertension and potentially heart failure occurs excessively in African-Caribbean-(AfC) and directly sub-Saharan-origin (Af) women. Curiously, hypertension is significantly associated with (i.e. coincides more frequently than...
by Samuel White | 11th September 2023
Precision medicine approaches are needed to revolutionise management an improve outcomes for patients with inflammatory bowel disease (IBD), a chronic immune mediated inflammatory disease of the gastrointestinal tract without a medical cure. Although there are...
by Samuel White | 11th September 2023
Neural stem cells (NSCs) are self-renewing multipotent progenitors that generate various cell types in the central nervous system (CNS). It is crucial to understand how NSCs regulate proliferation as this controls development, maintenance, and repair of the CNS, as...
by Samuel White | 11th September 2023
(i) Gum disease (periodontitis) is the leading cause of tooth loss in adults and is associated with numerous systemic diseases. Following surgical treatment, healing usually occurs by repair, but tissue regeneration is also possible. Current treatment protocols...
by Samuel White | 11th September 2023
During pregnancy insulin resistance increases and the maternal islets of Langerhans adapt by increasing both insulin secretory response and β-cell mass. Gestational diabetes (GDM) occurs when the islets are unable to adapt sufficiently. The signals underlying this...
by Samuel White | 11th September 2023
Novel immunotherapeutic treatments harnessing the capacity of T cells to recognize and kill tumour cells have improved disease outcomes in several types of cancer, but have not benefited patients with myeloid malignancies, such as Acute Myeloid Leukaemia (AML) and...
by Samuel White | 11th September 2023
The importance of cell-to-cell communication mediated by extracellular vesicles (EV) is gaining increasing attention. In patients with cancer, Tumour-derived EV can be readily detected, these can contain micro and other RNAs in addition to various chemokines and...
by Samuel White | 11th September 2023
The lymphatic network and lymph nodes act as sentinels of the immune system. Lymphatic vessels continually deliver tissue-derived signals for lymph node constituents to assess and initiate an immune response when needed. This system, however may be hijacked by tumours...
by Samuel White | 11th September 2023
Type 2 Diabetes (T2D) and obesity-related traits are global epidemics. In the UK alone, ~4 million people are living with diabetes and 10% of the NHS budget is spent on diabetes. A limitation to early detection and treatment of T2D is its diverse clinical presentation...
by Samuel White | 11th September 2023
Cellular plasticity, the ability of a cell to adopt alternative fates or acquire new identities, is relevant to diverse fields, including developmental and stem cell biology, regenerative medicine. Insights into these mechanisms could provide us with tools for...
