by admin | 28th September 2022
An appropriate choice of payload is critical to developing a successful antibody drug conjugate (ADC) for clinical development. However, problems such as efflux liability, non-selective toxicity, chemoresistance, poor pharmacokinetic and pharmacodynamic profiles of...
by admin | 28th September 2022
Eczema affects 1 in 20 adults, resulting in inflamed skin, disfigurement and poor quality of life. Response and side-effects of new treatments are unpredictable: 6 in 10 people receiving them fail to get clear/nearly clear skin, with up to 5 in 10 experiencing eye...
by admin | 7th September 2022
Project Description: Neural stem cells (NSCs) are self-renewing multipotent progenitors that generate various cell types in the central nervous system (CNS). It is crucial to understand how NSCs regulate proliferation as this controls development, maintenance, and...
by admin | 7th September 2022
Cellular plasticity, the ability of a cell to adopt alternative fates or acquire new identities, is relevant to diverse fields, including developmental and stem cell biology, regenerative medicine. Insights into these mechanisms could provide us with tools for...
by admin | 7th September 2022
More than 50% of people aged over 65 have age-related hearing impairment (ARHI). ARHI has considerable impact on health and well-being, from mild difficulty with communication to depression, social isolation and dementia. ARHI is heritable (h2=40%) but the underlying...
by admin | 7th September 2022
The innate immune system is the first line of defence against pathogens. When a bacteria or virus is sensed by our cells, there is potent upregulation of pro-inflammatory cytokines and other genes, which are critical to stop the infection. However, if inflammation is...
by admin | 7th September 2022
The junctional epithelium (JE) is an important group of epithelial cells that reside between the tooth and the oral mucosa. At the base of the JE is a putative epithelial stem cell niche (*) that replenishes the junctional epithelium. The region is defined by the...
by admin | 7th September 2022
Diffuse infiltrating low-grade gliomas (LGGs) are WHO grade 2 tumours that include oligodendrogliomas and astrocytomas. Despite their initially indolent nature, LGGs may cause considerable morbidity1 and frequently transform into higher grade lethal entities 2. The...
by admin | 7th September 2022
Severe refractory asthma is characterised by neutrophil-dominated lung inflammation. Neutrophils’ capacity to produce reactive oxygen species (ROS) via enzyme NADPH oxidase Nox2 is unmet by other immune cells. Neutrophil Nox2 represents the main source of superoxide...
by admin | 7th September 2022
This project, using data collected as part of the MRC-funded UNiCoRN Study (Understanding the causes of Hyperglycaemia in Pregnancy; MR/W003740/1) will explore the physiology of normal pregnancy across the spectrum of glycaemia, in this 750-strong prospective cohort...
by admin | 7th September 2022
Muscular dystrophies are a group of diseases that are characterised by muscle weakness, where muscle wastes and connective tissue becomes deregulated, so scar tissue forms. Oxidative stress from respiration is common to many muscular dystrophies. A common muscular...
by admin | 7th September 2022
Acute myeloid leukaemia (AML) in children remains a significant unmet. Most paediatric AML are characterised by gene fusions associated to clinical prognosis. This project aims to define the immunogenicity of noncanonical antigenic peptides derived from fusion genes...
