by Samuel White | 11th September 2023
Rationale: Alterations in the resolution of the immune response can lead to chronic inflammation, driving diseases such rheumatoid arthritis, atherosclerosis or obesity. Additionally, blocking the resolution phase can potentiate the immune response, desirable in...
by Samuel White | 11th September 2023
Sickle Cell Disease (SCD) is a blood disorder with a high disease-burden, affecting individuals of Black ancestry, and is associated with adverse pregnancy outcomes including maternal mortality (6x), pre-eclampsia & preterm birth (2x), growth restriction &...
by Samuel White | 11th September 2023
Prostate Cancer (PCa) is the most commonly diagnosed cancer in men, with nearly 140 new cases a day in UK. Patients are treated with drugs that reduce the level of the male sex hormone or block its activity, thus preventing the activation of the Androgen Receptor, the...
by Samuel White | 11th September 2023
Interleukin-36α/β/γ (IL-36) are cytokines that play an important role in skin inflammation. These molecules have also been implicated in anti-tumour immunity, as their expression is inversely correlated with the progression of lung and ovarian cancer. While the...
by Samuel White | 11th September 2023
Cellular plasticity, the ability of a cell to adopt alternative fates or acquire new identities, is relevant to diverse fields, including developmental and stem cell biology, regenerative medicine. Insights into these mechanisms could provide us with tools for...
