by admin | 7th September 2022
Background: Human globin genes, coding for hemoglobin, are differentially activated in the embryonic, fetal and adult stages of hematopoiesis. Mutations in adult globin genes result in hemoglobinopathies such as sickle cell anemia. Reactivating fetal hemoglobin (HbF)...
by admin | 7th September 2022
Pathogen-infections lead to immediate upregulation of host-defence-genes, also called interferon-stimulated-genes (ISG). Many pathogens, including influenza-A-virus (IAV) counteract host ISG-expression. IAV-infection de-regulates transcription-termination so that...
by admin | 7th September 2022
Systemic Lupus Erythematosus (SLE) is an autoimmune disease that affects millions of people worldwide. Strikingly 9/10 SLE cases are women, yet little is understood as to why. Hormonal and environmental factors are believed to be partly responsible, and while there is...
by admin | 7th September 2022
Cleft palate is a relatively common birth defect arising when the palatal shelves growing from the maxilla (upper jaw) fail to meet and fuse. Understanding this developmental process may help early diagnosis and avoid the costs and pain of the repeated surgeries...
by admin | 7th September 2022
Primary or adjuvant radiotherapy or chemo-radiotherapy are part of the curative treatment regime in head and neck squamous cell carcinoma (HNSCC). However, in >50% of high-risk patients, treatment resistance leads to loco-regional disease persistence or recurrence....
by admin | 7th September 2022
Precision medicine approaches are needed to revolutionise management an improve outcomes for patients with inflammatory bowel disease (IBD), a chronic immune mediated inflammatory disease of the gastrointestinal tract without a medical cure. Although there are...
by admin | 7th September 2022
Adult stem cells drive organ regeneration and homeostasis, but their dysregulation can lead to tumourigenesis or organ failure. Regenerative medicine aims to replace functional cells without triggering uncontrolled proliferation. A barrier to translation is our...
by admin | 7th September 2022
Cutaneous squamous cell carcinomas (cSCC) complicating the inherited blistering skin disease, recessive dystrophic epidermolysis bullosa (RDEB), is a strikingly aggressive cancer, with 87% of patients dying of metastatic disease by the age of 45 years. RDEB-cSCC arise...
by admin | 7th September 2022
We discovered a conserved process that drives most epithelial cell death called ‘cell extrusion’, essential to maintaining correct cell numbers and an intact barrier. Importantly, misregulation of extrusion drives tumor formation and invasion and asthma inflammation...
by admin | 7th September 2022
Ovarian ageing is a naturally occurring process that results in a gradual decline in ovarian function and cessation at menopause. In addition to declining fertility, ovarian ageing results in several metabolic and cognitive changes which increase the risk for...
by admin | 7th September 2022
Autoimmune destruction of insulin-producing β-cells of the pancreas results in Type 1 Diabetes (T1D), with an incidence rate of 25.4 out of 100,000 (0-14 years) in the UK. Despite improvement of care, to-date, there is no cure for T1D, presenting an urgent need for...
by admin | 7th September 2022
Type 1 diabetes (T1D) is an autoimmune disorder in which the destruction of insulin-secreting β-cells leads to an inability to regulate blood glucose appropriately, leading to a range of pathological consequences. We currently treat the symptoms of T1D with daily...
