1+ 3 Student
I graduated from University College London in 2018 with a MSci in Biological Sciences. During this time, I undertook a 6-month project in the UCL MRC Laboratory for Molecular Cell Biology where I investigated Sulfolobus as a model organism for the study of the archaeal cell cycle. In my second year, I was awarded funding by the Rank Prize Funds to investigate epigenetic changes associated with Non-alcoholic fatty liver disease within the Institute of Developmental Sciences, Southampton University. It was during these placements that I developed an interest in academia.
I choose the MRC DTP because of its wide range of projects available, extensive training opportunities (in the form of workshops and seminars) and the option to undertake rotations as part of the 1+3 programme. The rotation year not only widened my scientific knowledge base and technical skills repertoire but exposed me to varying approaches to research. Thanks to this, I am now conducting my PhD in a field I would never have considered before!
My PhD project focusses on using a newly characterised model of diabetes, the KINGS mouse, to investigate sex differences underlying pancreatic islet biology and its dysfunction in the Diabetes Research group under Dr Aileen King.
The KINGS Ins2+/G32S Mouse: A Novel Model of β-Cell Endoplasmic Reticulum Stress and Human Diabetes. Amazon L.F. Austin, Lydia F. Daniels Gatward, Miriam Cnop, Gabriel Santos, David Andersson, Sally Sharp, Clive Gentry, Stuart Bevan, Peter M. Jones, Aileen J.F. King. Diabetes. 2020
Practical Considerations when Using Mouse Models of Diabetes. Aileen J.F. King, Lydia F. Daniels Gatward and Matilda R. Kennard. Springer Methods and Protocols. 2020
DZD Diabetes Research School 2019: Poster presentation.
Diabetes UK 2020: Accepted oral presentation
EASD 2020: Poster presentation
Diabetes UK 2021: Poster presentation shortlisted for the Lily Diabetes Basic Science Awards
Insulin-100 2021: Poster presentation
- Investigating human regulatory T-cell subsets in autoimmunity and transplantation. (Dr Tim Tree)
- Investigating EGR1 upregulation in oral epithelial cells during the immediate response to Candida albicans infection. (Professor Julian Naglik and Dr David Moyes)
- Beta-cell proliferation in an endoplasmic reticulum stress-induced diabetic mouse model. (Dr Aileen King and Dr Pratik Choudhary)