There is currently a lack of predictors of immunotherapy response in colorectal cancer patients, making treatment challenging. A subpopulation of tumour-associated macrophages were recently identified to correlate with therapy response. However, it is unclear how these cells are involved in generating long-lasting anti-tumour responses. My project focusses on understanding the function and mechanism of these macrophages in response to immunotherapy in colorectal cancer using murine models and computational analysis.
I completed both my BSc in Medical Biosciences and MRes in Cancer Biology at Imperial College London. During my BSc research project, I studied the activation and function of receptor tyrosine kinase discoidin domain receptor 1 activation using site-directed mutagenesis to aid in the development of a kinase inhibitor for potential use as a cancer therapy. During my MRes I completed two research projects during which I worked at the Francis Crick Institute on the characterisation of combination therapies to potentiate the effect of KRAS-G12C inhibitors in non-small cell lung cancer. For my second project, I developed a multiplex immunohistochemistry pipeline for the characterisation of tumour-associated macrophages in high grade serous ovarian carcinoma.
I chose the DTP as the programme is student-centred and allows researchers to develop their skills alongside their PhD project, including training opportunities in bioinformatics and statistical analysis, which are both required for my research.
Linked In – Chloé Woodman