Chloé Woodman

Pathway 0+4 PhD

Cohort 2022

Pathway Journey

There is currently a lack of predictors of immunotherapy response in colorectal cancer patients, making treatment challenging. A subpopulation of tumour-associated macrophages were recently identified to correlate with therapy response. However, it is unclear how these cells are involved in generating long-lasting anti-tumour responses. My project focusses on understanding the function and mechanism of these macrophages in response to immunotherapy in colorectal cancer using murine models and computational analysis.

Biography

I completed both my BSc in Medical Biosciences and MRes in Cancer Biology at Imperial College London. During my BSc research project, I studied the activation and function of receptor tyrosine kinase discoidin domain receptor 1 activation using site-directed mutagenesis to aid in the development of a kinase inhibitor for potential use as a cancer therapy. During my MRes I completed two research projects during which I worked at the Francis Crick Institute on the characterisation of combination therapies to potentiate the effect of KRAS-G12C inhibitors in non-small cell lung cancer. For my second project, I developed a multiplex immunohistochemistry pipeline for the characterisation of tumour-associated macrophages in high grade serous ovarian carcinoma.

I chose the DTP as the programme is student-centred and allows researchers to develop their skills alongside their PhD project, including training opportunities in bioinformatics and statistical analysis, which are both required for my research.

Social Media

Linked In – Chloé Woodman