My research project is looking into the role of platelets in allergen sensitization.
It has been previously demonstrated that temporary depletion of platelets in a murine model of allergic airway inflammation, restricted to the time of allergen sensitization, resulted in suppression of allergic inflammation.
The aim of the project is to investigate what are the phenotypic changes of platelets and their progenitors – megakaryocytes – in response to allergen exposure, and what is their significance for effective allergen sensitization.
I obtained an MSci (Hons) degree from King’s College London in 2018, a part of which was a 6-month-long industrial placement project at Aptuit, Verona. I have then spent the next 3 years working there as a Research Scientist in the Translational Pharmacology department.
Russel, V., Brana, M., Pompilio, D., Ambrosi, G., Andeeta, F., Venturini, E., Chalidou, A., Manni, E (2018). Steroid-resistant inflammation in a mouse model of severe asthma is not inhibited by the combination of Theophylline and Budensonide. European Respiratory Journal, 52: Suppl. 62, PA1048.
Greenfield SA, Cole GM, Coen CW, Frautschy S, Singh RP, Mekkittikul M, Garcia-Ratés S, Morrill P, Hollings O, Passmore M, Hasan S, Carty N, Bison S, Piccoli L, Carletti R, Tacconi S, Chalidou A, Pedercini M, Kroecher T, Astner H, Gerrard PA. (2022). A novel process driving Alzheimer’s disease validated in a mouse model: Therapeutic potential. Alzheimers Dement (N Y). Apr 5;8(1):e12274. doi: 10.1002/trc2.12274. PMID: 35415206; PMCID: PMC8983808.