by Samuel White | 11th September 2023
Overview: Cognitive impairment in people with bipolar disorders (BD) impacts on daily functioning and is associated with poor illness prognosis and poor quality of life. Sleep disturbance is another core symptom of BD. Sleep disturbance experienced by people with BD...
by Samuel White | 11th September 2023
Accumulating evidence suggests that psychedelic drugs show therapeutic promise for a range of mental health conditions and have the potential to inform our understanding of the neural bases of psychopathology and perception. Despite recent progress, multiple lines of...
by Samuel White | 11th September 2023
Background: The hippocampus is a specialized brain region that governs learning, memory and mood. During ageing, the hippocampus shrinks and this is hypothesized to contribute to age-related cognitive decline. Within this PhD project, the student will use a...
by Samuel White | 11th September 2023
Overview/Mission Statement: This project aims to investigate the underlying mechanisms of neurodegeneration caused by the accumulation of alpha-synuclein (aSyn) in Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy...
by Samuel White | 11th September 2023
Scientific Basis: The WHO considers autism as a priority due to its high-frequency, early onset, and life-long impact on quality of life. Discovering mechanisms that predict which autistic person develops mental health problems (prognostic biomarker), and which...
by Samuel White | 11th September 2023
Eating disorders (ED) affect ~8% of the global population and they are often chronic and cause substantial costs. ED are complex with both genetic and environmental causes. Epigenetics, biological mechanisms that underlie the interaction between genes and the...
by Samuel White | 11th September 2023
Many people with major depressive disorder (MDD) are ambivalent about medication or therapeutic relationships. Using simple self-guided psychological strategies is a promising approach to meet their needs. In this project, based on our previous pilot clinical trials,...
by Samuel White | 11th September 2023
The formation of synaptic connections in the central nervous system relies on particular subsets of proteins that are also implicated in cognitive disorders such as Autistic Spectrum Disorder (ASD). While the formation of wiring is hence a key suspect in ASD, we...
by Samuel White | 11th September 2023
Autistic people are at high risk of experiencing co-occurring anxiety and depression. Current approaches to treating mental health in autism focus on adapting interventions for the neurotypical population which target symptoms rather than underlying mechanisms. In...
by Samuel White | 11th September 2023
The treatment of psychotic disorders uses trial and error, which means it often takes years to find the right treatment for patients, exposes them to side-effects and impairs recovery. Thus, there is a major clinical need for personalised treatment selection. Prior...
by Samuel White | 11th September 2023
Neurodegenerative diseases are currently incurable diseases that result in progressive neuronal degeneration. With the increase in the ageing population, it is estimated that 1 in 3 people born today will develop dementia or related disorders. Protein aggregation is a...
by Samuel White | 11th September 2023
Background: The schizophrenia whole disease model (WDM) developed by the applicants is the first health economic model which covers the entire schizophrenia care pathway in the UK, including prevention, diagnosis, and first-line and subsequent lines of treatment....