by Samuel White | 11th September 2023
Traumatic experiences are common, and often followed by emotional disorders (anxiety, depression, post-traumatic stress disorder (PTSD)). Nonetheless, most people who experience trauma do not develop an emotional disorder. These individual differences in developing...
by Samuel White | 11th September 2023
Epilepsy is typically understood as a disease where the brain represents a complex network with regions and/or sub-networks in which normal excitation/inhibition (E/I) balance is perturbed. The resulting repertoire of dynamics includes adverse effects such as...
by Samuel White | 11th September 2023
Anorexia nervosa (AN) is a disabling disorder typically beginning in adolescence. ~30% of patients respond poorly to psychotherapies, resulting in enduring illness, and the potential to impair development. We have pioneered non-invasive brain stimulation treatments in...
by Samuel White | 11th September 2023
The scientific basis of the project and (optional) translational aspects of the project, It was previously thought that depression preceded low self-esteem and that once the depression was treated, then self-esteem would also improve. However, a number of longitudinal...
by Samuel White | 11th September 2023
Mitochondria generate ATP, play key roles in cellular metabolism and are essential for neuronal function. Increasing evidence points to a central role of mitochondria in the aetiology of neuropsychiatric disorders, including schizophrenia, depression and anxiety....
by Samuel White | 11th September 2023
Mutations in epigenetic regulators have emerged as a significant risk factor for a diverse group of neurodevelopmental disorders, with most characterised by autism and intellectual disability. We have generated mouse models with mutations in these high risk genes that...
by Samuel White | 11th September 2023
The unique experience of pain is driven in part by the descending pain modulatory system (DPMS). Activity in DPMS-encompassed descending inhibitory pathways is altered in some chronic pain states. This PhD proposal is concerned with mapping the mechanisms that...
by Samuel White | 11th September 2023
Fibromyalgia is an incurable condition characterized by chronic widespread pain, fatigue, and emotional distress. Despite that >2% (mostly women) of the population live with fibromyalgia, there are no effective therapies. The mechanisms responsible remained unknown...
by Samuel White | 11th September 2023
Early-onset epilepsy is associated with poor developmental outcomes. Limited evidence suggests that specific maternal characteristics are associated with early-onset epilepsy, and that certain features of epilepsy predict diagnosis of neurodevelopmental conditions,...
by Samuel White | 11th September 2023
Background: Depression and anxiety rates are rising. These debilitating disorders impact all aspects of life. Psychological therapies are more widely available than ever, but only ~50% of those treated recover. We must find ways to get people into the right form of...
by Samuel White | 11th September 2023
Background: Synapse formation and maturation is arguably one of the most important steps to ensure the function of neural circuits during development. At the same time, synaptic defects and loss of synaptic functionality are common features across many...
by Samuel White | 11th September 2023
Background Functional neurological disorder (FND) is a common cause of significant disabling symptoms such as seizures, limb weakness or shaking that is poorly understood as it falls in the gaps between physical and mental health. There is no identifiable damage to...
