by admin | 7th September 2022
Mitochondria generate ATP, play key roles in cellular metabolism and are essential for neuronal function. Increasing evidence points to a central role of mitochondria in the aetiology of neuropsychiatric disorders, including schizophrenia, depression and anxiety....
by admin | 7th September 2022
Mutations in EPG5 cause Vici Syndrome, a neurodevelopmental disease associated with subsequent neurodegeneration. EPG5 encodes for a protein that regulates autophagy, by controlling the fusion between autophagosomes and lysosomes. Autophagy is an essential...
by admin | 7th September 2022
The scientific basis of the project and (optional) translational aspects of the project, It was previously thought that depression preceded low self-esteem and that once the depression was treated, then self-esteem would also improve. However, a number of longitudinal...
by admin | 7th September 2022
Characterizing brain development is a fundamental task in neuroscience. Yet, most developmental neuroimaging studies to-date have relied on cross-sectional data, which precludes investigation of developmental changes and has hampered progress in understanding the...
by admin | 7th September 2022
Anorexia nervosa (AN) is a disabling disorder typically beginning in adolescence. ~30% of patients respond poorly to psychotherapies, resulting in enduring illness, and the potential to impair development. We have pioneered non-invasive brain stimulation treatments in...
by admin | 7th September 2022
The adult mammalian brain is generally terrible at repairing itself, but some specialised regions can do it naturally. This project will leverage the unique regenerative ability of the olfactory system to ask how neuronal plasticity can influence functional recovery...
by admin | 7th September 2022
Epilepsy is typically understood as a disease where the brain represents a complex network with regions and/or sub-networks in which normal excitation/inhibition (E/I) balance is perturbed. The resulting repertoire of dynamics includes adverse effects such as...
by admin | 7th September 2022
Age is the major risk factor for many diseases, including diabetes, heart attack, cancer, and neurodegeneration. Genetic and environmental factors converge on hormonal pathways in the brain to affect the ageing process. These pathways are highly conserved, enabling...
by admin | 7th September 2022
Traumatic experiences are common, and often followed by emotional disorders (anxiety, depression, post-traumatic stress disorder (PTSD)). Nonetheless, most people who experience trauma do not develop an emotional disorder. These individual differences in developing...
by admin | 7th September 2022
The amygdala, a key limbic brain structure commonly known for its role in higher-order emotional processing, is implicated in stress-induced suppression of gonadotrophin-releasing hormone (GnRH) pulse generator frequency, to cause infertility. Our pioneering discovery...
by admin | 7th September 2022
Adolescents are thought to be more vulnerable to the harmful effects of cannabis than adults. Adolescents are reliably at a greater risk of developing cannabis use disorder (CUD) than adults. Cannabis addiction is the leading cause of <18-year-olds seeking drug...
by admin | 7th September 2022
At present, there are no medications for treatment of Autism core or co-occurring symptoms. There is evidence that the neurobiological underpinnings of ASD include aberrations in brain growth, neuronal patterning, cortical connectivity and altered molecular pathways...
