by Samuel White | 11th September 2023
Around 70% of children with autism have at least one additional psychiatric diagnosis, with emotional and behavioural problems being the most diagnosed and often requiring specialist interventions by mental health services. However, there is a poor understanding of...
by Samuel White | 11th September 2023
The role of mitochondria in complex diseases such as Parkinson’s Disease and Motor Neurone Disease is now becoming well established, however it is often not known whether altered mitochondrial processes play a causal role in developing disease, or occur as a...
by Samuel White | 11th September 2023
Cytoplasmic accumulation and nuclear depletion of TDP43 are key pathological hallmarks of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) (1). While there is progress in understanding disease progression, the early presymptomatic (prodromal) stages...
by Samuel White | 11th September 2023
Background: Anorexia nervosa (AN) is a serious psychiatric condition with the highest mortality rate of any psychiatric illness. The factors that perpetuate and maintain the illness remain elusive and in particular, understanding surrounding the neurobiology of AN is...
by Samuel White | 11th September 2023
Functional Neurological Disorders (FNDs) are common causes of neurological symptoms such as seizures, limb weakness, movement disorders and sensory changes without structural neuropathology. There is increasing evidence of an association with autism in both adults and...
by Samuel White | 11th September 2023
Mutations in EPG5 cause Vici Syndrome, a neurodevelopmental disease associated with subsequent neurodegeneration. EPG5 encodes for a protein that regulates autophagy, by controlling the fusion between autophagosomes and lysosomes. Autophagy is an essential...
by Samuel White | 11th September 2023
Introduction: There is a potential link between neurodegenerative diseases and disordered proteins forming amyloids, which subsequently trigger calcification of brain tissues. In our research laboratories, we have discovered indicative calcification patterns occurring...
by Samuel White | 11th September 2023
Background: Acknowledging sleep health as a key marker of overall health and the adoption of a systems approach to its study, promotion, and amelioration led to major developments in sleep research. Sleep is recognised as a proxy of health rather than the mere...
by Samuel White | 11th September 2023
Neurodevelopmental Disorders (NDD), including intellectual disability and autism spectrum disorder, are a common group of conditions, affecting up to 3% of the general population, with significant societal impact. Yet, the molecular and cellular mechanisms disrupting...
by Samuel White | 11th September 2023
Chronic pain is a complex and distressing problem affecting ~1 billion people world-wide – equivalent to the population of China. We know that how we think and feel about our bodies can influence pain perception and the risk of developing chronic pain. What we don’t...
by Samuel White | 11th September 2023
At present, there are no medications for treatment of Autism core or co-occurring symptoms. There is evidence that the neurobiological underpinnings of ASD include aberrations in brain growth, neuronal patterning, cortical connectivity and altered molecular pathways...
by Samuel White | 11th September 2023
Adolescents are thought to be more vulnerable to the harmful effects of cannabis than adults. Adolescents are reliably at a greater risk of developing cannabis use disorder (CUD) than adults. Cannabis addiction is the leading cause of 75% of cases). However, the...
