by admin | 7th September 2022
The role of mitochondria in complex diseases such as Parkinson’s Disease and Motor Neurone Disease is now becoming well established, however it is often not known whether altered mitochondrial processes play a causal role in developing disease, or occur as a...
by admin | 7th September 2022
In this project we will use a coherent in vitro, experimental, systematic approach, to mimic early-life stress (ELS)-relevant cortisol and inflammatory insults on cells from the human brain, heart, liver, pancreas and blood immune system, to identify mechanisms...
by admin | 7th September 2022
Migraine is the leading cause of years lost to disability in young females, impacting over 1-billion people globally. Sleep, under the regulation of circadian and light-dark cycles is intrinsically linked with migraine, with sleep disruption a commonly reported...
by admin | 7th September 2022
Around 70% of children with autism have at least one additional psychiatric diagnosis, with emotional and behavioural problems being the most diagnosed and often requiring specialist interventions by mental health services. However, there is a poor understanding of...
by admin | 7th September 2022
The generation of skilled upper limb movements relies on a complex neuronal network including several cerebral cortical and sub-cortical areas. The processing of multi-modal sensory information and its efficient transfer across this network are critical to produce...
by admin | 7th September 2022
Alcohol Use Disorder (AUD) is a highly prevalent disorder. The World Health Organisation has estimated that approximately 3 million people die each year from the harmful use of alcohol. Psychological interventions and pharmacological treatments are widely available,...
by admin | 7th September 2022
Chronic pain is a complex and distressing problem affecting ~1 billion people world-wide – equivalent to the population of China. We know that how we think and feel about our bodies can influence pain perception and the risk of developing chronic pain. What we don’t...
by admin | 7th September 2022
Neurodevelopmental Disorders (NDD), including intellectual disability and autism spectrum disorder, are a common group of conditions, affecting up to 3% of the general population, with significant societal impact. Yet, the molecular and cellular mechanisms disrupting...
by admin | 7th September 2022
To mitigate the ill consequences of psychosis on people’s life, the NHS and the economy, clinicians increasingly focus on early intervention. Here, the aim is to prevent psychosis from occurring in people at risk of the condition. One way to improve our ability to...
by admin | 7th September 2022
Background: Acknowledging sleep health as a key marker of overall health and the adoption of a systems approach to its study, promotion, and amelioration led to major developments in sleep research. Sleep is recognised as a proxy of health rather than the mere...
by admin | 7th September 2022
Background: Autism Spectrum Disorders (ASD) is a highly diverse and heterogeneous condition. Histopathology and neuroimaging studies in children and adults with a diagnosis of ASD have shown subtle disruptions in the organisation of their neural systems. Understanding...
by admin | 7th September 2022
Introduction: There is a potential link between neurodegenerative diseases and disordered proteins forming amyloids, which subsequently trigger calcification of brain tissues. In our research laboratories, we have discovered indicative calcification patterns occurring...
