by Samuel White | 11th September 2023
In this project we will use a coherent in vitro, experimental, systematic approach, to mimic early-life stress (ELS)-relevant cortisol and inflammatory insults on cells from the human brain, heart, liver, pancreas and blood immune system, to identify mechanisms...
by Samuel White | 11th September 2023
Epilepsy is the most common and highest impact neurological disorder and there are no medical cures because the pathophysiological brain mechanisms are poorly understood. The condition arises from excitation-inhibition imbalance in neocortical networks, with...
by Samuel White | 11th September 2023
Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in approx. 1.5 per 1000 live births at term and is associated with significant mortality and long-term morbidity, up to 50% of neonates having a severe outcome of death or disability. Outcomes can also include...
by Samuel White | 11th September 2023
Scientific Basis: The WHO considers autism as a priority due to its high-frequency, early onset, and life-long impact on quality of life. Discovering mechanisms that predict which autistic person develops mental health problems (prognostic biomarker), and which...
by Samuel White | 11th September 2023
Background: Abnormalities of the neurotransmitter system GABA are consistent findings in post-mortem and preclinical studies in psychosis. GABAergic abnormalities have been linked to not only psychotic symptoms but also cognitive deficits that are not treated...
by Samuel White | 11th September 2023
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two clinically different neurodegenerative diseases that lie on a pathogenic spectrum. The most common pathology present in ALS and FTD cases is cytoplasmic mislocalisation and aggregation of...
by Samuel White | 11th September 2023
Laws regulating cannabis are rapidly changing globally, with Uruguay, Canada, and several US states now permitting recreational use. Concurrently, cannabis potency (of ∆9-tetrahydrocannabinol, THC) has increased in most parts of the world, and research suggests...
by Samuel White | 11th September 2023
Change in appetite and weight are core symptoms of depression, but little is known about the relationship between them and their biological underpinnings. The genetic contribution to most mental health disorders and human behaviour is polygenic, with many genetic...
by Samuel White | 11th September 2023
Remote measurement technology (RMT) has transformed longitudinal remote monitoring of research participants and offers unique translational potential. This project uses data from our large RMT study on adults and adolescents with attention deficit hyperactivity...
by Samuel White | 11th September 2023
Autophagy is a self-degradation mechanism necessary to clear aggregate prone proteins that accumulate in neurodegenerative diseases such as in Alzheimer’s disease (AD). For this reason, investigating the mechanisms that regulate autophagy are currently explored as...
by Samuel White | 11th September 2023
mRNAs are found not only in neuronal cell bodies but also in axons and dendrites, where many re locally translated. These local mechanisms are important for proper neuronal development and adult neurological functions. Alternative splicing of mRNAs produces various...
by Samuel White | 11th September 2023
Atypical depression (AD) is characterised by mood reactivity, interpersonal rejection sensitivity, hyperphagia, hypersomnia and/or leaden immobility (DSM-IV). Atypical features are reported in 15-30% of patients with major depression, and are associated with early...
