by admin | 7th September 2022
Change in appetite and weight are core symptoms of depression, but little is known about the relationship between them and their biological underpinnings. The genetic contribution to most mental health disorders and human behaviour is polygenic, with many genetic...
by admin | 7th September 2022
The cerebral cortex is the seat of many of the higher cognitive functions that make us human, such as our advanced learning and speech. We know that the correct organisation of the cortex is vital for these functions, but how this is achieved during development...
by admin | 7th September 2022
Laws regulating cannabis are rapidly changing globally, with Uruguay, Canada, and several US states now permitting recreational use. Concurrently, cannabis potency (of ∆9-tetrahydrocannabinol, THC) has increased in most parts of the world, and research suggests...
by admin | 7th September 2022
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two clinically different neurodegenerative diseases that lie on a pathogenic spectrum. The most common pathology present in ALS and FTD cases is cytoplasmic mislocalisation and aggregation of...
by admin | 7th September 2022
Background: Abnormalities of the neurotransmitter system GABA are consistent findings in post-mortem and preclinical studies in psychosis. GABAergic abnormalities have been linked to not only psychotic symptoms but also cognitive deficits that are not treated...
by admin | 7th September 2022
Scientific Basis: The WHO considers autism as a priority due to its high-frequency, early onset, and life-long impact on quality of life. Discovering mechanisms that predict which autistic person develops mental health problems (prognostic biomarker), and which...
by admin | 7th September 2022
Functional Neurological Disorders (FNDs) are common causes of neurological symptoms such as seizures, limb weakness, movement disorders and sensory changes without structural neuropathology. There is increasing evidence of an association with autism in both adults and...
by admin | 7th September 2022
There has been an increasing interest in the potential of remote assessment technologies in healthcare settings (e.g., electronic patient reported outcomes [ePROs]) to allow additional information to inform decision making. Until the Covid-19 pandemic these...
by admin | 7th September 2022
Background: Anorexia nervosa (AN) is a serious psychiatric condition with the highest mortality rate of any psychiatric illness. The factors that perpetuate and maintain the illness remain elusive and in particular, understanding surrounding the neurobiology of AN is...
by admin | 7th September 2022
Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in approx. 1.5 per 1000 live births at term and is associated with significant mortality and long-term morbidity, up to 50% of neonates having a severe outcome of death or disability. Outcomes can also include...
by admin | 7th September 2022
Cytoplasmic accumulation and nuclear depletion of TDP43 are key pathological hallmarks of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) (1). While there is progress in understanding disease progression, the early presymptomatic (prodromal) stages...
by admin | 7th September 2022
Epilepsy is the most common and highest impact neurological disorder and there are no medical cures because the pathophysiological brain mechanisms are poorly understood. The condition arises from excitation-inhibition imbalance in neocortical networks, with...
