by Samuel White | 11th September 2023
People with autism are much more likely to experience mental health difficulties than the general population; around 70% have at least one comorbid psychiatric disorder. We have developed a novel, specialist care pathway for this population in close collaboration with...
by Samuel White | 11th September 2023
In the UK, and globally, fatal drug overdoses are at an all-time high1,2. Opioid overdose is now the leading cause of death for people under the age of 50 in the US2. An effective antidote to opioid, Naloxone, exists but many people are alone when they overdose3,4 and...
by Samuel White | 11th September 2023
Overview: Cognitive impairment in people with bipolar disorders (BD) is associated with reduced functional capacity, poor illness prognosis, and poor quality of life. Sleep disturbance is another core BD symptom which may be associated with, and perhaps worsen,...
by Samuel White | 11th September 2023
Tele-health is a core component of the UK mental health care in the NHS 5-year plan. Whilst the implementation was rapidly accelerated during the pandemic, it relies on the technological resources available in the mental health care services and on patients’ ability...
by Samuel White | 11th September 2023
Background: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease characterised by misregulation of the RNA binding protein TDP-43. A major challenge has been the lack of good TDP-43 disease models, thereby limiting ‘bench to bedside’ success. However,...
by Samuel White | 11th September 2023
Background Iron dyshomeostasis has been observed in Alzheimer’s Disease (AD) [1]. We have suggested that ferroptosis, a form of iron-enhanced programmed cell death, operates in AD [2], and arises from excess lethal lipids as detoxification mechanisms are overwhelmed...
by Samuel White | 11th September 2023
Malan syndrome is a rare genetic overgrowth disorder, which is clinically characterized by unusual facial features and macrocephaly associated with intellectual disability. Whilst Nfix transcription factor has been identified as a causal gene of the syndrome, the...
by Samuel White | 11th September 2023
Congenital heart disease (CHD) affects almost 1% of UK births, and is the most frequent congenital malformation. Improvements in antenatal diagnosis, cardiac surgery, and perioperative care mean that most infants born with CHD now survive. However, children and adults...
by Samuel White | 11th September 2023
Sexual minority people (e.g., lesbian, gay and bisexual) are at substantially higher risk of multiple health problems, including mental and physical health (Semelyen et al. BMC Psychitr 16, Article 67, 2016). However, the measurement of sexual minority status as...
by Samuel White | 11th September 2023
Children differ dramatically in how easily they learn skills such as reading and mathematics and in how well they use these skills to learn more generally. These skills are among the most heritable behavioural traits and the DNA revolution is making it possible to...
by Samuel White | 11th September 2023
The brain is made of billions of neurons which communicate with each other via synapses. Synapse formation (synaptogenesis), function, plasticity, and maintenance – processes crucial for normal brain development and function – are all controlled by cholesterol....
by Samuel White | 11th September 2023
Scientific basis: The neuronal processing that enables us to see and recognise complex visual images like text and faces starts in the retina itself. Diseases leading to photoreceptor death cause irreversible sight loss, and yet the rest of the inner retinal circuitry...
