by admin | 7th September 2022
In the UK, and globally, fatal drug overdoses are at an all-time high1,2. Opioid overdose is now the leading cause of death for people under the age of 50 in the US2. An effective antidote to opioid, Naloxone, exists but many people are alone when they overdose3,4 and...
by admin | 7th September 2022
People with autism are much more likely to experience mental health difficulties than the general population; around 70% have at least one comorbid psychiatric disorder. We have developed a novel, specialist care pathway for this population in close collaboration with...
by admin | 7th September 2022
Human induced pluripotent stem cells (hiPSCs) derived from patients with neurological disease are an invaluable source to study the development of central nervous system disorders such as epilepsy. In a novel approach, we will investigate if hiPSCs from epilepsy...
by admin | 7th September 2022
Up to 40% of autistic individuals have epilepsy. The combination of autism and epilepsy significantly impacts upon quality of life as well as physical and mental health. The majority of studies to date have been retrospective investigations after a diagnosis of autism...
by admin | 7th September 2022
Scientific basis: The neuronal processing that enables us to see and recognise complex visual images like text and faces starts in the retina itself. Diseases leading to photoreceptor death cause irreversible sight loss, and yet the rest of the inner retinal circuitry...
by admin | 7th September 2022
Respiratory failure is the leading cause of morbidity and mortality following spinal cord injury (Fig 1). There currently exists no clinical treatment for this and respiratory muscle function is not typically monitored following spinal cord injury. We hypothesise that...
by admin | 7th September 2022
The brain is made of billions of neurons which communicate with each other via synapses. Synapse formation (synaptogenesis), function, plasticity, and maintenance – processes crucial for normal brain development and function – are all controlled by cholesterol....
by admin | 7th September 2022
Recent epidemiological studies established an association between transient maternal hypothyroidism in early pregnancy and autism spectrum disorder (ASD). We have developed a robust mouse model of ASD where offspring born from a mother with induced transient...
by admin | 7th September 2022
Atypical depression (AD) is characterised by mood reactivity, interpersonal rejection sensitivity, hyperphagia, hypersomnia and/or leaden immobility (DSM-IV). Atypical features are reported in 15-30% of patients with major depression, and are associated with early...
by admin | 7th September 2022
mRNAs are found not only in neuronal cell bodies but also in axons and dendrites, where many re locally translated. These local mechanisms are important for proper neuronal development and adult neurological functions. Alternative splicing of mRNAs produces various...
by admin | 7th September 2022
Autophagy is a self-degradation mechanism necessary to clear aggregate prone proteins that accumulate in neurodegenerative diseases such as in Alzheimer’s disease (AD). For this reason, investigating the mechanisms that regulate autophagy are currently explored as...
by admin | 7th September 2022
Remote measurement technology (RMT) has transformed longitudinal remote monitoring of research participants and offers unique translational potential. This project uses data from our large RMT study on adults and adolescents with attention deficit hyperactivity...
