by admin | 28th September 2022
The global research into therapeutics for neurodegenerative diseases is rapidly generating new candidate therapeutic approaches, especially new small molecules and gene therapy vectors. However, the bottleneck in translating these to clinical trials is the need to...
by admin | 7th September 2022
The brain is made of billions of neurons which communicate with each other via synapses. Synapse formation (synaptogenesis), function, plasticity, and maintenance – processes crucial for normal brain development and function – are all controlled by cholesterol....
by admin | 7th September 2022
Recent epidemiological studies established an association between transient maternal hypothyroidism in early pregnancy and autism spectrum disorder (ASD). We have developed a robust mouse model of ASD where offspring born from a mother with induced transient...
by admin | 7th September 2022
Children differ dramatically in how easily they learn skills such as reading and mathematics and in how well they use these skills to learn more generally. These skills are among the most heritable behavioural traits and the DNA revolution is making it possible to...
by admin | 7th September 2022
Many people with major depressive disorder (MDD) are ambivalent about medication or therapeutic relationships. Self-guided virtual-reality(VR)-assisted therapy is a promising approach to meet their needs. In this project, based on our previous VR-based self-assessment...
by admin | 7th September 2022
Sexual minority people (e.g., lesbian, gay and bisexual) are at substantially higher risk of multiple health problems, including mental and physical health (Semelyen et al. BMC Psychitr 16, Article 67, 2016). However, the measurement of sexual minority status as...
by admin | 7th September 2022
Project Description: Research has shown that women experience more symptoms of depression and are more likely to be diagnosed with depression than men. These differences in prevalence only become evident after the onset of puberty. This raises the possibility that...
by admin | 7th September 2022
Congenital heart disease (CHD) affects almost 1% of UK births, and is the most frequent congenital malformation. Improvements in antenatal diagnosis, cardiac surgery, and perioperative care mean that most infants born with CHD now survive. However, children and adults...
by admin | 7th September 2022
Malan syndrome is a rare genetic overgrowth disorder, which is clinically characterized by unusual facial features and macrocephaly associated with intellectual disability. Whilst Nfix transcription factor has been identified as a causal gene of the syndrome, the...
by admin | 7th September 2022
Eating disorders (EDs) are common and disabling mental disorders. Processes that help or hinder recovery are poorly understood. Remote Measurement Technology (RMT) uses inbuilt sensors in smartphones and/or wearables to: (a) unobtrusively measure human behaviour and...
by admin | 7th September 2022
Background Iron dyshomeostasis has been observed in Alzheimer’s Disease (AD) [1]. We have suggested that ferroptosis, a form of iron-enhanced programmed cell death, operates in AD [2], and arises from excess lethal lipids as detoxification mechanisms are overwhelmed...
by admin | 7th September 2022
Background: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease characterised by misregulation of the RNA binding protein TDP-43. A major challenge has been the lack of good TDP-43 disease models, thereby limiting ‘bench to bedside’ success. However,...
