by Samuel White | 19th October 2023
Migraine is a disabling disorder that significantly impacts quality of life, with recurrent attacks of severe headache. Attacks are intrinsically linked with head pain; however, patients commonly report several non-pain symptoms hours to days before the headache that...
by Samuel White | 11th September 2023
Scientific basis: Eating disorders (EDs) are common and disabling mental disorders. Processes that help or hinder recovery are poorly understood. Remote Measurement Technology (RMT) uses inbuilt sensors in smartphones and/or wearables to: (a) unobtrusively measure...
by Samuel White | 11th September 2023
(i) Scientific basis of project: The amygdala, a key limbic brain structure commonly known for its role in higher-order emotional processing, is implicated in stress-induced suppression of gonadotrophin-releasing hormone (GnRH) pulse generator frequency, to cause...
by Samuel White | 11th September 2023
There has been an increasing interest in the potential of remote assessment technologies in healthcare settings (e.g., electronic patient reported outcomes [ePROs]) to allow additional information disease experience and mental health to inform decision making. The...
by Samuel White | 11th September 2023
Scientific basis and translational potential The generation of skilled upper limb movements relies on a complex neuronal network including several cerebral cortical and sub-cortical areas. The processing of multi-modal sensory information and its efficient transfer...
by Samuel White | 11th September 2023
Alcohol Use Disorder (AUD) is a highly prevalent disorder. The World Health Organisation has estimated that approximately 3 million people die each year from the harmful use of alcohol. Psychological interventions and pharmacological treatments are widely available,...
by Samuel White | 11th September 2023
Age is the major risk factor for many diseases, including diabetes, heart disease, cancer, and neurodegeneration. Genetic and environmental factors converge on hormonal pathways in the brain to affect the ageing process. These pathways are highly conserved, enabling...
by Samuel White | 11th September 2023
Recent epidemiological studies established an association between transient maternal hypothyroidism in early pregnancy and autism spectrum disorder (ASD). We have developed a robust mouse model of ASD where offspring born from a mother with induced transient...
by Samuel White | 11th September 2023
Respiratory failure is the leading cause of morbidity and mortality following spinal cord injury (Fig 1). There currently exists no clinical treatment for this and respiratory muscle function is not typically monitored following spinal cord injury. We hypothesise that...
by Samuel White | 11th September 2023
Up to 40% of autistic individuals have epilepsy. The combination of autism and epilepsy significantly impacts upon quality of life as well as physical and mental health. The majority of studies to date have been retrospective investigations after a diagnosis of autism...
by Samuel White | 11th September 2023
Human induced pluripotent stem cells (hiPSCs) derived from patients with neurological disease are an invaluable source to study the development of central nervous system disorders such as epilepsy. In a novel approach, we will investigate if hiPSCs from epilepsy...
by Samuel White | 11th September 2023
People with autism are much more likely to experience mental health difficulties than the general population; around 70% have at least one comorbid psychiatric disorder. We have developed a novel, specialist care pathway for this population in close collaboration with...
