by Samuel White | 11th September 2023
Scientific basis: Multi-drug resistant bacterial pathogens are frequent causes of hospital acquired infections which are often difficult to diagnose and treat. Pathogenic bacteria produce and small molecules with high iron affinity (Kaff >1025) known as...
by Samuel White | 11th September 2023
Hypertrophic cardiomyopathy (HCM) is a poorly understood, heritable cardiac disease affecting > 1 in 500 persons. HCM is characterised by progressive enlargement of the primary pumping chamber of the heart, the left ventricle, wherein the heart muscle is abnormally...
by Samuel White | 11th September 2023
Background: Cardiac magnetic resonance imaging (CMR) is widely regarded as the gold-standard imaging modality for evaluating cardiac structure, function, and viability. However, a significant rate of non-diagnostic scans (up to 25-50%) is observed in patients with...
by Samuel White | 11th September 2023
Background: Coronary microvascular disease (cMVD) is a syndrome characterised by anginal chest pain, fatigue, and shortness of breath. More prevalent in women, it is caused by dysfunction of the smallest vessels in the heart, causing transient diffuse patchy...
by Samuel White | 11th September 2023
Lung cancer is the leading cause of cancer related death worldwide. The presence of malignant mediastinal lymph nodes (MLNs) is important in determining disease stage and appropriate treatment. Non-invasive screening methods using CT and/or PET have low sensitivity...
by Samuel White | 11th September 2023
Huntington’s Disease (HD) is an inherited neurodegenerative disorder caused by a CAG (codon that codes for amino acid glutamine) repeat expansion in the huntingtin gene (HTT). The prevalence of HD varies by ethnic origin and occurs mainly in Caucasian populations....
by Samuel White | 11th September 2023
Background MRI is an incredibly successful medical imaging modality, with 3.8 million scans acquired in the NHS in the year preceding March 2022. However, MR imaging in young children is difficult. Scanners are built to fit the largest adults, resulting in suboptimal...
by Samuel White | 11th September 2023
Most lung cancer deaths result from ineffective treatment of late-stage disease. Currently, there is no satisfactory way to identify patients that will not respond to standard-of-care treatments. Positron emission tomography (PET) imaging offers a potential solution...
by Samuel White | 11th September 2023
Semantic segmentation of brain structures from medical images, in particular Magnetic Resonance Imaging (MRI), plays an important role in many neuroimaging applications. Deep learning based segmentation algorithms are now achieving state-of-the-art segmentation...
by Samuel White | 11th September 2023
For brain tumours, X-ray radiotherapy is used to reduce tumour bulk, treat inoperable tumours or secondary brain tumours. However, quality of life remains affected, and metastases and relapses still occur. Other, more targeted forms of radiotherapy are now being...
by Samuel White | 11th September 2023
Background: The clinical success of alveolar bone regeneration using implants is typically determined using radiography or visually by the surgeon. This has major limitations as neither of these approaches offer insights into the integrity and tissue formation at the...
by Samuel White | 11th September 2023
Fetal MRI is an exciting, rapidly evolving field due to the use of advanced motion correction protocols and the advent of functional imaging. These have enabled assessment of not only fetal anatomy but also tissue function. Necrotising Enterocolitis (NEC) is a...
