Project ID NS-MH2026_62

ThemeNS-MH

Co Supervisor 1A Prof Edmund Sonuga-Barke Institute of Psychiatry, Psychology & Neuroscience, School of Academic Psychiatry, Department of Child & Adolescent PsychiatryEmail

Co Supervisor 1B Dr Mark Kennedy Institute of Psychiatry, Psychology & Neuroscience, School of Academic Psychiatry, Department of Child & Adolescent PsychiatryEmail

Third Supervisor Dr Divyangana Rakesh

The Impact of Global Childhood Deprivation on Mid-Life Outcomes: Pathways to Successful Outcomes in the English and Romanian Adoptees (ERA) Study

(a) The scientific basis of the project, including any (optional) translational aspects

The English & Romanian Adoptees study (ERA) is the largest developmental study of people who experienced prolonged, early and severe institutional deprivation. Key findings from ERA include; (a) a devastating initial global impact on nearly all adoptees; (b) remarkable rapid catch-up for most; (c) residual marked and strongly persistent neuro-developmental problems for the majority who experienced extended deprivation; (d) a profound secondary impact of these on daily functioning, social relationships and mental health in early adulthood; and (e) a mediating role for socio-cognitive and brain processes. Importantly these effects seemed to be independent of pre-existing risk or adoption selection effects. As the adoptees enter mid-life (now in their mid-30’s), ERA offers a unique opportunity to undertake the first, large scale, study of the effects impact of institutional deprivation on mental health, wellbeing and functioning in middle adulthood. Preliminary feasibility work shows that participant retainment is sufficient for these analyses.

(b) The techniques and skills the student will develop

Data collection and analysis (quantitative and qualitative) e.g., advanced multivariate longitudinal modelling & reflexive thematic analysis
Instrument a selection and adaptation – questionnaires, interviews, focus groups
Neuroimaging data skills
Translational skills

(c) A clear definition of the overarching aims of the project

We aim:
1. To investigate transitions from early adulthood (YAF: Young Adulthood Follow-up) to mid adulthood (MAF: Mid Adulthood Follow-up) in terms of what predicts successful transitions (incl neuroimaging data)
2. To characterise the risks, opportunities, and key changes during this transition
3. To follow-up on early signs of deterioration of mental health identified at YAF
4. To follow-up on incomplete transitions and high support needs identified at YAF
5. To investigate transitions to parenthood

(d) Specific, measurable objectives for each year of the PhD (Years 1–4), with additional detail for Year 1

Year 1 – literature review and ethics. The literature review will focus on (un)successful transitions to mid-adulthood in general and in adopted samples (ie mental health, employment, social relationships, parenthood etc)
Year 2 – data collection and analysis
Year 3 – finalising analysis and starting write up
Year 4 – finalising write up, dissemination and delivering CPD to partner organisations (e.g., CoramBAAF, Barnardos, AoCPP, BASW)

(e) A summary of a potential 3-month rotation project (for students on the MRes + PhD pathway)

One area of challenge and support provision among adoptees is identity formation and maintaining a positive identity. However, very little is known about the persistence into adulthood/ what predicts whether problems persist or remit. In this project, a student would focus on exploring data around participants’ adoption-related identity, what factors predict positive/negative experiences and what role these experiences play in predicting outcomes (e.g., mental health and functional). This could be carried out either at the Denmark Hill campus or remotely.

Representative Publications

Sonuga-Barke, E. J., Kennedy, M., Kumsta, R., Knights, N., Golm, D., Rutter, M., … & Kreppner, J. (2017). Child-to-adult neurodevelopmental and mental health trajectories after early life deprivation: the young adult follow-up of the longitudinal English and Romanian Adoptees study. The Lancet, 389(10078), 1539-1548. https://doi.org/10.1016/S0140-6736(17)30045-4

 

Van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Duschinsky, R., Fox, N. A., Goldman, P. S., Gunnar, M. R., … & Sonuga-Barke, E. J. (2020). Institutionalisation and deinstitutionalisation of children 1: A systematic and integrative review of evidence regarding effects on development. The Lancet Psychiatry, 7(8), 703-720. https://doi.org/10.1016/S2215-0366(19)30399-2

 

Mackes, N. K., Mehta, M. A., Beyh, A., Nkrumah, R. O., Golm, D., Sarkar, S., … & Sonuga-Barke, E. J. (2022). A prospective study of the impact of severe childhood deprivation on brain White matter in adult adoptees: widespread localized reductions in volume but unaffected microstructural organization. Eneuro, 9(6). https://doi.org/10.1523/ENEURO.0188-22.2022

 

Kennedy, M., Kreppner, J., Knights, N., Kumsta, R., Maughan, B., Golm, D., … & Sonuga‐Barke, E. J. (2016). Early severe institutional deprivation is associated with a persistent variant of adult attention‐deficit/hyperactivity disorder: clinical presentation, developmental continuities and life circumstances in the English and Romanian Adoptees study. Journal of Child Psychology and Psychiatry, 57(10), 1113-1125. https://doi.org/10.1111/jcpp.12576

 

Kennedy, M., Kreppner, J., Knights, N., Kumsta, R., Maughan, B., Golm, D., … & Sonuga-Barke, E. (2017). Adult disinhibited social engagement in adoptees exposed to extreme institutional deprivation: examination of its clinical status and functional impact. The British Journal of Psychiatry, 211(5), 289-295. https://doi.org/10.1192/bjp.bp.117.200618

 

Edwards, C., Kennedy, M., Knights, N., Kovshoff, H., Kreppner, J., Maughan, B., & Sonuga-Barke, E. J. (2023). When people adopted from severely depriving institutions become parents: The experiences of young adult mothers from the ERA study and their adoptive parents. Adoption & Fostering, 47(4), 415-433. https://doi.org/10.1177/03085759231212500