Project ID NS-MH2023_42


Co Supervisor 1A IoPPN/Forensic & Neurodevelopmental SciencesWebsite

Co Supervisor 1B FoLSM/Perinatal Imaging, Biomedical Engineering and Imaging SciencesWebsite

The effect of neonatal hypoxic ischaemic encephalopathy on anatomical and functional memory circuits and later childhood memory function

Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in approx. 1.5 per 1000 live births at term and is associated with significant mortality and long-term morbidity, up to 50% of neonates having a severe outcome of death or disability.

Outcomes can also include cerebral palsy and cognitive impairments, often related to patterns of injury detected on neonatal MRI. However, approximately 25% of neonates with HIE will have a “normal” MRI and are traditionally considered to have a good long-term outcome. This is not the full picture, recent studies report long-term deficits in memory and cognition that may relate to disruptions in the Papez circuit, crucial for memory function (e.g. Annink et al, 2021) and sensitive to injury in hypoxia.

Here, we will test this hypothesis, utilising an MRI dataset of infants with HIE, scanned while at hospital. These infants will be compared to a large, well-characterised reference cohort of over 800 term born control neonates collected as part of the developing Human Connectome Project (dHCP) with high resolution structural and diffusion MRI acquired with an identical acquisition. The student will test whether alterations in hippocampal volumes and Papez subcortical network connections underlie long-term memory problems assessed in this cohort at childhood age (6-10 years).

Objectives –
Year 1: Learn neonatal image data analysis, test the associations between brain MRI and clinical variables associated with HIE (e.g. presence of seizures).
Year 2. Collect follow-up imaging and neurodevelopmental assessments (cognition and memory).
Year 3. Test association between longitudinal brain imaging and childhood memory/cognitive function.

Annink, K.V., de Vries, L.S., Groenendaal, F. et al. Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy. Sci Rep 11, 5017 (2021).

One representative publication from each co-supervisor:

O’Muircheartaigh, Jonathan, Emma Robinson, Maximillian Pietsch… & A David Edwards 2020. ‘Modelling Brain Development to Detect White Matter Injury in Term and Preterm Born Neonates.’ Brain: A Journal of Neurology 143 (2): 467–79.

Carney, Olivia, Emer Hughes, Nora Tusor… & Mary Rutherford 2021. “Incidental findings on brain MR imaging of asymptomatic term neonates in the Developing Human Connectome Project.” EClinicalMedicine 38 (2021): 100984.