by Samuel White | 11th September 2023
Neurodevelopmental Disorders (NDD), including intellectual disability and autism spectrum disorder, are a common group of conditions, affecting up to 3% of the general population, with significant societal impact. Yet, the molecular and cellular mechanisms disrupting...
by Samuel White | 11th September 2023
Background: Acknowledging sleep health as a key marker of overall health and the adoption of a systems approach to its study, promotion, and amelioration led to major developments in sleep research. Sleep is recognised as a proxy of health rather than the mere...
by Samuel White | 11th September 2023
Introduction: There is a potential link between neurodegenerative diseases and disordered proteins forming amyloids, which subsequently trigger calcification of brain tissues. In our research laboratories, we have discovered indicative calcification patterns occurring...
by Samuel White | 11th September 2023
Mutations in EPG5 cause Vici Syndrome, a neurodevelopmental disease associated with subsequent neurodegeneration. EPG5 encodes for a protein that regulates autophagy, by controlling the fusion between autophagosomes and lysosomes. Autophagy is an essential...
by Samuel White | 11th September 2023
The importance of cell-to-cell communication mediated by extracellular vesicles (EV) is gaining increasing attention. In patients with cancer, Tumour-derived EV can be readily detected, these can contain micro and other RNAs in addition to various chemokines and...
by Samuel White | 11th September 2023
The lymphatic network and lymph nodes act as sentinels of the immune system. Lymphatic vessels continually deliver tissue-derived signals for lymph node constituents to assess and initiate an immune response when needed. This system, however may be hijacked by tumours...
by Samuel White | 11th September 2023
Type 2 Diabetes (T2D) and obesity-related traits are global epidemics. In the UK alone, ~4 million people are living with diabetes and 10% of the NHS budget is spent on diabetes. A limitation to early detection and treatment of T2D is its diverse clinical presentation...
by Samuel White | 11th September 2023
Cellular plasticity, the ability of a cell to adopt alternative fates or acquire new identities, is relevant to diverse fields, including developmental and stem cell biology, regenerative medicine. Insights into these mechanisms could provide us with tools for...
by Samuel White | 11th September 2023
More than 50% of people aged over 65 have age-related hearing impairment (ARHI). ARHI has considerable impact on health and well-being, from mild difficulty with communication to depression, social isolation and dementia. ARHI is heritable (h2=40%) but the underlying...
by Samuel White | 11th September 2023
The innate immune system is the first line of defence against pathogens. When a bacteria or virus is sensed by our cells, there is potent upregulation of pro-inflammatory cytokines and other genes, which are critical to stop the infection. However, if inflammation is...
by Samuel White | 11th September 2023
The junctional epithelium (JE) is an important group of epithelial cells that reside between the tooth and the oral mucosa. At the base of the JE is a putative epithelial stem cell niche (*) that replenishes the junctional epithelium. The region is defined by the...
by Samuel White | 11th September 2023
Severe refractory asthma is characterised by neutrophil-dominated lung inflammation. Neutrophils’ capacity to produce reactive oxygen species (ROS) via enzyme NADPH oxidase Nox2 is unmet by other immune cells. Neutrophil Nox2 represents the main source of superoxide...