Understanding lymph node determinants of therapy response

The lymphatic network and lymph nodes act as sentinels of the immune system. Lymphatic vessels continually deliver tissue-derived signals for lymph node constituents to assess and initiate an immune response when needed. This system, however may be hijacked by tumours...

Regulation of the innate immune response by N4BP1

The innate immune system is the first line of defence against pathogens. When a bacteria or virus is sensed by our cells, there is potent upregulation of pro-inflammatory cytokines and other genes, which are critical to stop the infection. However, if inflammation is...

Redox-regulation in neutrophilic asthma

Severe refractory asthma is characterised by neutrophil-dominated lung inflammation. Neutrophils’ capacity to produce reactive oxygen species (ROS) via enzyme NADPH oxidase Nox2 is unmet by other immune cells. Neutrophil Nox2 represents the main source of superoxide...