by Samuel White | 11th September 2023
Background: Abnormalities of the neurotransmitter system GABA are consistent findings in post-mortem and preclinical studies in psychosis. GABAergic abnormalities have been linked to not only psychotic symptoms but also cognitive deficits that are not treated...
by Samuel White | 11th September 2023
Scientific Basis: The WHO considers autism as a priority due to its high-frequency, early onset, and life-long impact on quality of life. Discovering mechanisms that predict which autistic person develops mental health problems (prognostic biomarker), and which...
by Samuel White | 11th September 2023
Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in approx. 1.5 per 1000 live births at term and is associated with significant mortality and long-term morbidity, up to 50% of neonates having a severe outcome of death or disability. Outcomes can also include...
by Samuel White | 11th September 2023
Epilepsy is the most common and highest impact neurological disorder and there are no medical cures because the pathophysiological brain mechanisms are poorly understood. The condition arises from excitation-inhibition imbalance in neocortical networks, with...
by Samuel White | 11th September 2023
In this project we will use a coherent in vitro, experimental, systematic approach, to mimic early-life stress (ELS)-relevant cortisol and inflammatory insults on cells from the human brain, heart, liver, pancreas and blood immune system, to identify mechanisms...
by Samuel White | 11th September 2023
Mitochondria generate ATP, play key roles in cellular metabolism and are essential for neuronal function. Increasing evidence points to a central role of mitochondria in the aetiology of neuropsychiatric disorders, including schizophrenia, depression and anxiety....
by Samuel White | 11th September 2023
The scientific basis of the project and (optional) translational aspects of the project, It was previously thought that depression preceded low self-esteem and that once the depression was treated, then self-esteem would also improve. However, a number of longitudinal...
by Samuel White | 11th September 2023
Anorexia nervosa (AN) is a disabling disorder typically beginning in adolescence. ~30% of patients respond poorly to psychotherapies, resulting in enduring illness, and the potential to impair development. We have pioneered non-invasive brain stimulation treatments in...
by Samuel White | 11th September 2023
Epilepsy is typically understood as a disease where the brain represents a complex network with regions and/or sub-networks in which normal excitation/inhibition (E/I) balance is perturbed. The resulting repertoire of dynamics includes adverse effects such as...
by Samuel White | 11th September 2023
Traumatic experiences are common, and often followed by emotional disorders (anxiety, depression, post-traumatic stress disorder (PTSD)). Nonetheless, most people who experience trauma do not develop an emotional disorder. These individual differences in developing...
by Samuel White | 11th September 2023
Adolescents are thought to be more vulnerable to the harmful effects of cannabis than adults. Adolescents are reliably at a greater risk of developing cannabis use disorder (CUD) than adults. Cannabis addiction is the leading cause of 75% of cases). However, the...
by Samuel White | 11th September 2023
At present, there are no medications for treatment of Autism core or co-occurring symptoms. There is evidence that the neurobiological underpinnings of ASD include aberrations in brain growth, neuronal patterning, cortical connectivity and altered molecular pathways...