Project ID NS-MH2024_57


Co Supervisor 1A Institute of Psychiatry, Psychology & Neuroscience, School of Academic Psychiatry, Department of Psychological MedicineWebsite

Co Supervisor 1B Institute of Psychiatry, Psychology & Neuroscience, School of Academic Psychiatry, Department of Psychological MedicineWebsite

Exploring links between sleep and cognitive impairment in people with bipolar disorders

Overview: Cognitive impairment in people with bipolar disorders (BD) impacts on daily functioning and is associated with poor illness prognosis and poor quality of life. Sleep disturbance is another core symptom of BD. Sleep disturbance experienced by people with BD may be associated with, and perhaps worsen, cognitive and functional difficulties. A recent review which we conducted suggested an association between sleep disturbance and cognitive impairment in BD, and this may persist during periods of normal mood (euthymia). However, little is known about the changes in the brain that occur during sleep in people with BD (sleep architecture) and whether abnormalities in these changes may be associated with cognitive impairment.

This project will use in-home EEG polysomnography to investigate different sleep stages and sleep architecture, and how this relates to cognitive function in euthymic people with BD compared to healthy participants. The project aims to investigate links between sleep architecture measured by EEG and cognitive impairment in BD. We hope doing this may help to identify new potential treatment targets.

Training: The project will be supervised by two leading researchers in mood disorders, Dr Stokes & Prof Young, both members of the International Society for Bipolar Disorders Targeting Cognition Taskforce. Additionally, Dr Scott Cairney (University of York), an expert in sleep and sleep architecture will be a third external supervisor. The PhD candidate will undergo training in conducting and interpreting polysomnography sleep EEG recordings, neurocognitive assessments, and mood questionnaires. The project will also involve learning to recruit and interact with participants.

Year 1: Training, study set-up and participant recruitment.
Year 2: Administration of participant sleep EEG polysomnography and neurocognitive assessments.
Year 3: Analysis, write-up of thesis and publications, and presentation of results at an international conference.

Representative Publications

Neural Correlates of Working Memory function in Euthymic People with Bipolar Disorder Compared to Healthy Controls: A Systematic Review and Meta-analysis. Saldarini, F., Gottlieb, N. & Stokes, P., 15 Jan 2022, Journal of Affective disorders. 297, p. 610-622 DOI: 10.1016/j.jad.2021.10.084

The relationship between sleep disturbance and cognitive impairment in mood disorders: A systematic review. Pearson, O., Uglik-Marucha, E., Miskowiak, K., Cairney, S., Rosenzweig, I., Young, A. & Stokes, P. Journal of Affective Disorders. April 2023 327, 207–216. DOI: 10.1016/j.jad.2023.01.114

Can magnetic resonance imaging enhance the assessment of potential new treatments for cognitive impairment in mood disorders?: A systematic review and position paper by the International Society for Bipolar Disorders Targeting Cognition Task Force. Miskowiak, K. W., Yalin, N., Seeberg, I., et al., Vieta, E. & Stokes, PRA. Bipolar Disorders, Sep 2022, 24, 6, p. 615-636. DOI: 10.1111/bdi.13247

Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative. Burdick K et al., Cleare, A. et al, Strawbridge, B. et al , Young, A. et al , Nov 2022, Bipolar Disorders. 24, 7, p. 709-719 DOI: 10.1111/bdi.13208

Cognitive Remediation Therapy for patients with bipolar disorder: A randomised proof-of-concept trial: CRT for bipolar disorders. Strawbridge, B., Tsapekos, D., Hodsoll, J., Mantingh, T., Yalin, N., McCrone, P., Kankam-Boadu, J. B., Macritchie, K., Cella, M., Reeder, C., Fish, J., Wykes, T. & Young, A., 1 Mar 2021. Bipolar Disorders. 23, 2, p. 198-208. DOI: 10.1111/bdi.12968

The effects of psilocybin on cognitive and emotional functions in healthy participants: Results from a phase 1, randomised, placebo-controlled trial involving simultaneous psilocybin administration and preparation. Rucker, J. J., Marwood, L., Ajantaival, R-L. J., Bird, C., Eriksson, H., Harrison, J., Lennard-Jones, M., Mistry, S., Saldarini, F., Stansfield, S., Tai, S. J., Williams, S., Weston, N., Malievskaia, E. & Young, A. H., Jan 2022, Journal of Psychopharmacology. 36, 1, p. 114-125 12. DOI: 10.1177/02698811211064720