by Samuel White | 19th September 2025
(a) The scientific basis of the project, including any (optional) translational aspects The English & Romanian Adoptees study (ERA) is the largest developmental study of people who experienced prolonged, early and severe institutional deprivation. Key findings...
by Samuel White | 19th September 2025
Cognitive changes are central to psychosis and, according to those with lived experience, among the most impactful challenges in daily life. However, cognition is not static — it fluctuates in response to factors such as sleep, symptom expression, and substance use...
by Samuel White | 19th September 2025
This project provides the opportunity to develop and apply static and dynamic measures of functional connectivity, as indexed by resting-state functional MRI, in health and disease. Investigations championed by the successful applicant will provide new mechanistic...
by Samuel White | 19th September 2025
Motor neuron disease and frontotemporal disease (MND/FTD) are two overlapping devastating neurodegenerative disease, for which aggregation of TDP-43 is a core feature. However, this pathology is not present throughout the brain, but localised to specific ‘disease...
by Samuel White | 19th September 2025
This project builds on a novel and potentially unifying discovery: the well-established synaptotoxic effects of amyloid-β (Aβ) require the presence of α-synuclein, a protein classically associated with Parkinson’s disease (PD). This finding offers a rare mechanistic...
by Samuel White | 19th September 2025
Over 100,000 people in the UK have a stroke each year. Arm weakness is the most prevalent impairment, and recovery is often poor, limiting functional independence. The most effective therapy for motor recovery is high repetition movement practice. However, this is...
by Samuel White | 19th September 2025
Mental illnesses contribute to nearly 30% of the global burden of non-communicable diseases. Rapid environmental changes, ranging from urbanisation to climate stress and to changes in our personal environment, have altered how we live, with growing evidence that these...
by Samuel White | 19th September 2025
One of the most fascinating aspects of Attention-Deficit/Hyperactivity Disorder (ADHD) is its highly variable lifetime course. Some individuals improve in adolescence showing remission while others continue to experience significant symptoms, showing persistence. One...
by Samuel White | 19th September 2025
Scientific basis Fused-in-sarcoma (FUS), an RNA binding protein, is a central player in the genetics and pathology of ALS/FTD. Synaptic dysfunction is an early event in neurodegeneration but how this leads to neuron death is not known. Recent evidence clearly show...
by Samuel White | 19th September 2025
There is increasing evidence to indicate that glutathione (GSH), the main brain antioxidant, is abnormal in schizophrenia and may provide a new treatment target. In this study we plan to determine whether Diroximel Fumarate (DRF) (currently a treatment for a brain...
by Samuel White | 19th September 2025
Fibromyalgia is a common chronic pain condition (affecting 2-5% of people), characterized by unrelenting widespread pain and fatigue which significantly reduces a person’s quality of life. Like many other forms of chronic pain, fibromyalgia mostly affects women and is...
by Samuel White | 19th September 2025
Background: Immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA), carry a substantial mental health burden. In a cohort of 20,000 RA patients, we have shown that rates of depression have been rising, with 60% of RA patients experiencing...
