by Samuel White | 11th September 2023
The primary treatment for breast cancer is surgery, which does not achieve complete removal of all the tumour in 25% of patients who therefore require a further operation. This is then often followed by chemotherapy, radiotherapy and endocrine treatment. The aim of...
by Samuel White | 11th September 2023
It has been estimated that more than 10 million deaths per year will occur by 2050 due to antimicrobial resistance (AMR). Therefore, there is an urgent need to develop novel infection-specific imaging techniques that can be translated into clinical practice as early...
by Samuel White | 11th September 2023
Scientific basis: Eating disorders (EDs) are common and disabling mental disorders. Processes that help or hinder recovery are poorly understood. Remote Measurement Technology (RMT) uses inbuilt sensors in smartphones and/or wearables to: (a) unobtrusively measure...
by Samuel White | 11th September 2023
(i) Scientific basis of project: The amygdala, a key limbic brain structure commonly known for its role in higher-order emotional processing, is implicated in stress-induced suppression of gonadotrophin-releasing hormone (GnRH) pulse generator frequency, to cause...
by Samuel White | 11th September 2023
There has been an increasing interest in the potential of remote assessment technologies in healthcare settings (e.g., electronic patient reported outcomes [ePROs]) to allow additional information disease experience and mental health to inform decision making. The...
by Samuel White | 11th September 2023
Scientific basis and translational potential The generation of skilled upper limb movements relies on a complex neuronal network including several cerebral cortical and sub-cortical areas. The processing of multi-modal sensory information and its efficient transfer...
by Samuel White | 11th September 2023
Alcohol Use Disorder (AUD) is a highly prevalent disorder. The World Health Organisation has estimated that approximately 3 million people die each year from the harmful use of alcohol. Psychological interventions and pharmacological treatments are widely available,...
by Samuel White | 11th September 2023
Are the lipids forming the plasma membrane, organelles and nuclear envelope (NE) dynamically modified under mechanical stress? Lipids and proteins are key components of membranes, yet most of the effort to understand mechanotransduction has focused on proteins alone....
by Samuel White | 11th September 2023
The nucleus is a key eukaryotic organelle that must grow and restructure in each cell cycle. Tight control of nuclear shape and size is essential for proper cell function, and aberrant regulation of interphase nuclear morphology has been implicated in aging and...
by Samuel White | 11th September 2023
High blood pressure evolving into hypertension and potentially heart failure occurs excessively in African-Caribbean-(AfC) and directly sub-Saharan-origin (Af) women. Curiously, hypertension is significantly associated with (i.e. coincides more frequently than...
by Samuel White | 11th September 2023
Age is the major risk factor for many diseases, including diabetes, heart disease, cancer, and neurodegeneration. Genetic and environmental factors converge on hormonal pathways in the brain to affect the ageing process. These pathways are highly conserved, enabling...
by Samuel White | 11th September 2023
Precision medicine approaches are needed to revolutionise management an improve outcomes for patients with inflammatory bowel disease (IBD), a chronic immune mediated inflammatory disease of the gastrointestinal tract without a medical cure. Although there are...
