by Samuel White | 11th September 2023
RNA-binding proteins (RBPs) coordinate posttranscriptional gene expression via multiple mechanisms, including modulating coding and ncRNA processing and maturation, subcellular localisation or RNA translation. Many RBPs are now known to be deregulated or mutated in...
by Samuel White | 11th September 2023
We discovered a conserved process that drives most epithelial cell death called ‘cell extrusion’, essential to maintaining correct cell numbers and an intact barrier. Importantly, misregulation of extrusion drives tumor formation and invasion and asthma inflammation...
by Samuel White | 11th September 2023
Autoimmune destruction of insulin-producing β-cells of the pancreas results in Type 1 Diabetes (T1D), with an incidence rate of 25.4 out of 100,000 (0-14 years) in the UK. Despite improvement of care, to-date, there is no cure for T1D, presenting an urgent need for...
by Samuel White | 11th September 2023
In virtual reality (VR) environments, individuals can be placed in an immersive world where the nature of reality can be inconspicuously manipulated. This state-of-the-art technique has a clear potential for altering exercise workload perception, as altering visual,...
by Samuel White | 11th September 2023
Mutations in the genes encoding for cardiac myosin and associated proteins are the most common case of inheritable hypertrophic cardiomyopathy (HCM) a disease with a world-wide incidence of 1:500. HCM is functionally characterized by an impaired relaxation of the...
by Samuel White | 11th September 2023
Type 1 diabetes (T1D) is an autoimmune disorder in which the destruction of insulin-secreting β-cells leads to an inability to regulate blood glucose appropriately, leading to a range of pathological consequences. We currently treat the symptoms of T1D with daily...
by Samuel White | 11th September 2023
Ovarian ageing is a naturally occurring process that results in a gradual decline in ovarian function and cessation at menopause. In addition to declining fertility, ovarian ageing results in several metabolic and cognitive changes which increase the risk for...
by Samuel White | 11th September 2023
Cutaneous squamous cell carcinomas (cSCC) complicating the inherited blistering skin disease, recessive dystrophic epidermolysis bullosa (RDEB), is a strikingly aggressive cancer, with 87% of patients dying of metastatic disease by the age of 45 years. RDEB-cSCC arise...
by Samuel White | 11th September 2023
Primary or adjuvant radiotherapy or chemo-radiotherapy are part of the curative treatment regime in head and neck squamous cell carcinoma (HNSCC). However, in >50% of high-risk patients, treatment resistance leads to loco-regional disease persistence or recurrence....
by Samuel White | 11th September 2023
Background: RSAD2 (viperin) is an iron-sulphur [FeS] enzyme synthesising nucleotide analogue 3’-deoxy-3’,4’-didehydro-CTP (ddhCTP) . The protein expression is induced in response to viral infection and in many cancer cells (Human Protein Atlas). It restricts viral...
by Samuel White | 11th September 2023
Adult stem cells drive organ regeneration and homeostasis, but their dysregulation can lead to tumourigenesis or organ failure. Regenerative medicine aims to replace functional cells without triggering uncontrolled proliferation. A barrier to translation is our...
by Samuel White | 11th September 2023
Cancer metastasis accounts for most cancer-related deaths. To invade surrounding tissues, cancer cells need to migrate through dense and constricted spaces, which results in high mechanical stress on the nucleus, a large and stiff organelle. This can lead to nuclear...